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科研机构
上海药物研究所 [300]
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期刊论文 [294]
会议论文 [6]
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2021 [9]
2020 [14]
2019 [17]
2018 [31]
2017 [38]
2016 [17]
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The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/12/16
Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment
期刊论文
NANO TODAY, 2021, 卷号: 40, 页码: 14
作者:
Tang, Yisi
;
Fan, Wufa
;
Chen, Guihua
;
Zhang, Meng
;
Tang, Xueping
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/12/01
Cancer therapeutic vaccine
Legumain
Tumor-associated macrophage
Trichosanthin
Liposome
Adjuvant
A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8
作者:
Zhou, Jun
;
Zhan, Yan
;
Zhong, Dafang
;
Chen, Xiaoyan
;
Zhang, Yifan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/11/04
chimmitecan
mass spectrometry
pharmacokinetics
simmitecan
solid tumors
Synthesis and biological evaluation of novel cabazitaxel analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 41, 页码: 12
作者:
Ren, Sumei
;
Zhang, Minmin
;
Wang, Yujie
;
Guo, Jia
;
Wang, Junfei
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/08/17
Tritium extraction
Hydrogen isotopes
Eutectic Pb-Li
Fusion fuel cycle
Cabazitaxel
Docetaxel
Taxel
Anticancer
Semi-synthesis
10-Deacetylbaccatin III
Cytotoxicity
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845
作者:
Che, Jinxin
;
Wang, Zhilong
;
Shen, Zheyuan
;
Zhuang, Weihao
;
Ying, Huazhou
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
cancer metastasis
CXCR1
CXCR2
selectivity
antagonist
1,5-dihydro-4H-imidazol-4-one
Molecular Dynamics Simulations Based on 1-Phenyl-4-Benzoyl-1-Hydro-Triazole ERR alpha Inverse Agonists
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 7, 页码: 14
作者:
Gao, Zhipei
;
Du, Yongli
;
Sheng, Xiehuang
;
Shen, Jingkang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
ERRα
inverse agonists
1-phenyl-4-benzoyl-1-hydro-triazole
MD simulations
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:
Wu, Qian
;
Chen, Dan-Qi
;
Sun, Lin
;
Huan, Xia-Juan
;
Bao, Xu-Bin
收藏
  |  
浏览/下载:116/0
  |  
提交时间:2021/05/24
N2817
Bivalent BET inhibitors
Monovalent BET inhibitors
TAF1
Anticancer activity
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Dai, Meng-di
;
Wang, Yue-liang
;
Fan, Jun
;
Dai, Yang
;
Ji, Yin-chun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
receptor tyrosine kinase
FGFR inhibitor
DW14383
antitumor activity
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