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学科主题:Biochemistry & Molecular Biology
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Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease
期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 157, 期号: x, 页码: 82-91
作者:
Xia, Chun-Li
;
Tang, Gui-Hua
;
Guo, Yan-Qiong
;
Xu, You-Kai
;
Huang, Zhi-Shu
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/04/22
Neurodegenerative Diseases
Directed Ligands
Tree
Constituents
Design
Derivatives
Flavonoids
Decade
Target
Beta
Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 卷号: 291, 期号: 27, 页码: 14373-14384
作者:
Wang, T
;
Xu, WC
;
Qin, ML
;
Yang, Y
;
Bao, PH
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  |  
浏览/下载:29/0
  |  
提交时间:2016/09/14
NEURODEGENERATIVE DISEASES
AAA-ATPASE
OXIDATIVE STRESS
QUALITY-CONTROL
PROTEIN VCP
SUMO
COMPLEX
DEGRADATION
PROTEOSTASIS
MECHANISMS
Autoinhibitory Structure of the WW Domain of HYPB/SETD2 Regulates Its Interaction with the Proline-Rich Region of Huntingtin
期刊论文
STRUCTURE, 2014, 卷号: 22, 期号: 3, 页码: 378-386
作者:
Gao, YG
;
Yang, H
;
Zhao, J
;
Jiang, YJ
;
Hu, HY
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  |  
浏览/下载:22/0
  |  
提交时间:2015/07/22
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
作者:
Zhu, Jinmei
;
Wu, Chun-Feng
;
Li, Xiaobing
;
Wu, Gui-Sheng
;
Xie, Shan
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  |  
浏览/下载:29/0
  |  
提交时间:2013/10/16
Alzheimer's Disease
Acetylcholinesterase
Butyrylcholinesterase
Molecular Modeling
2-aminobenzimidazole
Phenotyping of Tianma-Stimulated Differentiated Rat Neuronal B104 Cells by Quantitative Proteomics
期刊论文
NEUROSIGNALS, 2012, 卷号: 20, 期号: 1, 页码: 48-60
作者:
Sundaramurthi, Husvinee
;
Manavalan, Arulmani
;
Ramachandran, Umamaheswari
;
Hu, Jiang-Miao
;
Sze, Siu Kwan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2012/06/07
Itraq Technology
Neural Cell Adhesion Molecule 1
Neurodegenerative Diseases
Tianma
The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease
期刊论文
METALLOMICS, 2012, 卷号: 4, 期号: 3, 页码: 289-296
作者:
Wang HJ(王华建)
;
Wang M(王萌)
;
Wang B(汪冰)
;
Wang, HJ
;
Wang, M
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  |  
浏览/下载:10/0
  |  
提交时间:2016/04/08
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation
期刊论文
HUMAN MOLECULAR GENETICS, 2009, 卷号: 18, 期号: 22, 页码: 4268-4281
作者:
Zhou, Jiawei
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  |  
浏览/下载:62/0
  |  
提交时间:2012/07/13
AMYOTROPHIC-LATERAL-SCLEROSIS
RETICULUM-ASSOCIATED DEGRADATION
MOTOR-NEURON DEATH
TRANSMEMBRANE CONDUCTANCE REGULATOR
PROTEIN-QUALITY CONTROL
MACHADO-JOSEPH-DISEASE
CELL-RECEPTOR SUBUNITS
N-TERMINAL HUNTINGTIN
LINKED MUTANT SOD1
HMG-COA REDUCTASE
Natural Antioxidants Protect Neurons in Alzheimer's Disease and Parkinson's Disease
期刊论文
NEUROCHEMICAL RESEARCH, 2009, 卷号: 34, 期号: 4, 页码: 630-638
Zhao, Baolu
;
赵保路
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2013/12/25
Oxidative stress
Green tea polyphenols
Nicotine
Genistein
Neurodegenerative diseases
Alzheimer's disease (AD)
Parkinson's disease (PD)
Acceleration of alpha-synuclein aggregation by homologous peptides
期刊论文
FEBS LETTERS, 2006, 卷号: 580, 期号: 15, 页码: 3657-3664
作者:
Du, HN
;
Li, HT
;
Zhang, F
;
Lin, XJ
;
Shi, JH
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2015/07/22
alpha-synuclein
GAV motif
aggregation
fibrillization
homologous peptide
Parkinson's disease
An unstructured region is required by GAV homologue for the fibrillization of host proteins
期刊论文
PROTEIN JOURNAL, 2005, 卷号: 24, 期号: 4, 页码: 209-218
作者:
Ji, LN
;
Du, HN
;
Zhang, F
;
Li, HT
;
Luo, XY
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2015/07/22
alpha-synuclein
amyloidogenic protein
fibrillization
GAV homologue
unstructured regions
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