An unstructured region is required by GAV homologue for the fibrillization of host proteins

	An unstructured region is required by GAV homologue for the fibrillization of host proteins
	Ji, LN; Du, HN; Zhang, F; Li, HT; Luo, XY; Hu, J; Hu, HY
刊名	PROTEIN JOURNAL
	2005
卷号	24 期号:4 页码:209-218
关键词	alpha-synuclein amyloidogenic protein fibrillization GAV homologue unstructured regions
通讯作者	Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Prote, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn
英文摘要	Accumulating evidence shows that some amyloidogenic proteins contain core sequences, which are critical for their fibrillization. Core sequences of alpha-synuclein, beta-amyloid peptide and prion protein usually reside in their unfolded regions and share a conserved consensus (VGGAVVAGV) designated as GAV homologue. Here we investigate the role of unfolded regions in fibrillization after GAV homologue is attached to the C-terminus or inserted into the loop regions of different host proteins, namely alpha -Syn(1-65), gamma-synuclein, E. coli thioredoxin and immunoglobulin G binding B1 domain of streptococcal protein G. The results imply that an unstructured region is required by GAV homologue for the fibrillization of host proteins. A number of amyloidogenic proteins with core sequences located in unstructured regions are summarized and discussed in details. The finding may provide further insight into the elucidating of the molecular mechanism underlying the fibrillization of alpha-Syn, A beta and PrP as well as other amyloidogenic proteins.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	AMYLOID-LIKE FIBRILS ; OCULOPHARYNGEAL MUSCULAR-DYSTROPHY ; ATOMIC-FORCE MICROSCOPY ; S PRION PROTEIN ; ALPHA-SYNUCLEIN ; ALZHEIMERS-DISEASE ; NEURODEGENERATIVE DISEASES ; IN-VITRO ; HUNTINGTONS-DISEASE ; PARKINSONS-DISEASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000233246300002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1893]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ji, LN,Du, HN,Zhang, F,et al. An unstructured region is required by GAV homologue for the fibrillization of host proteins[J]. PROTEIN JOURNAL,2005,24(4):209-218.
APA	Ji, LN.,Du, HN.,Zhang, F.,Li, HT.,Luo, XY.,...&Hu, HY.(2005).An unstructured region is required by GAV homologue for the fibrillization of host proteins.PROTEIN JOURNAL,24(4),209-218.
MLA	Ji, LN,et al."An unstructured region is required by GAV homologue for the fibrillization of host proteins".PROTEIN JOURNAL 24.4(2005):209-218.