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科研机构
上海药物研究所 [10]
昆明植物研究所 [1]
烟台海岸带研究所 [1]
内容类型
期刊论文 [12]
发表日期
2020 [12]
学科主题
Chemistry [1]
Polymer Sc... [1]
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A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor
期刊论文
CELL RESEARCH, 2020, 页码: 11
作者:
Sun, Wen
;
Chen, Li-Nan
;
Zhou, Qingtong
;
Zhao, Li-Hua
;
Yang, Dehua
收藏
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浏览/下载:84/0
  |  
提交时间:2020/12/24
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12
作者:
Han, Fanghui
;
Ning, Mengmeng
;
Cao, Hua
;
Ye, Yangliang
;
Feng, Ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Soft drug
TGR5
GLP-1
Gallbladder-filling effects
Rapid metabolism
Carboxylic ester
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
The triterpenoid sapogenin (2 alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling
期刊论文
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 9, 页码: 10
作者:
Xie, Zhifu
;
Jiang, Haowen
;
Liu, Wei
;
Zhang, Xinwen
;
Chen, Dakai
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Structural insights into the activation of GLP-1R by a small molecule agonist
期刊论文
CELL RESEARCH, 2020, 页码: 3
作者:
Ma, Honglei
;
Huang, Wei
;
Wang, Xiaoxi
;
Zhao, Lihua
;
Jiang, Yi
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  |  
浏览/下载:37/0
  |  
提交时间:2020/12/24
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 13
作者:
Yuliantie, Elita
;
Darbalaei, Sanaz
;
Dai, Antao
;
Zhao, Peishen
;
Yang, Dehua
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
Glucose-dependent insulinotropic peptide receptor
Glucagon-like peptide-1 receptor
Biased agonist
GPCR signaling
Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice
期刊论文
ACS OMEGA, 2020, 卷号: 5, 期号: 22, 页码: 12865-12876
作者:
Zhu, Xiaozhen
;
Zhang, Xia
;
Yi, Yuetao
;
Meng, Xianyao
;
Jia, Chenchen
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
CHAIN FATTY-ACIDS
INTEGRATED BIOMARKER RESPONSE
INSULIN SENSITIVITY
GUT MICROBIOTA
ENERGY-EXPENDITURE
INFLAMMATION
FRUCTANS
BENEFITS
HEALTH
FIBER
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Ning, Meng-meng
;
Yang, Wen-ji
;
Guan, Wen-bo
;
Gu, Yi-pei
;
Feng, Ying
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
ulcerative colitis
dextran sulfate sodium
dipeptidyl peptidase 4
sitagliptin
glucagon-like peptide-2
GLP-2(3-33)
apoptosis
proliferation
Activation of the GLP-1 receptor by a non-peptidic agonist
期刊论文
NATURE, 2020, 页码: 432-+
作者:
Zhao, Peishen
;
Liang, Yi-Lynn
;
Belousoff, Matthew J.
;
Deganutti, Giuseppe
;
Fletcher, Madeleine M.
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
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