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上海药物研究所 [5]
西北高原生物研究所 [1]
心理研究所 [1]
昆明植物研究所 [1]
海洋研究所 [1]
合肥物质科学研究院 [1]
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期刊论文 [11]
发表日期
2020 [11]
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Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 12, 页码: 2272-2298
作者:
Ding, Chunyong
;
Song, Zilan
;
Shen, Ancheng
;
Chen, Tingting
;
Zhang, Ao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
Immunotherapy
Anti-tumor
cGAS
STING
TBK1
Small molecule modulators
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 6
作者:
Hu, Wen-juan
;
Chang, Lu
;
Yang, Ying
;
Wang, Xin
;
Xie, Yuan-chao
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/21
remdesivir
pharmacokinetics
tissue distribution
nucleotide monophosphate
nucleotide triphosphate
nucleoside
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:
Wang, Ying
;
Zhu, Yao
;
Niu, Junxing
;
Deng, Qiangqiang
;
Guo, Shimeng
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/12/21
Bile acid analog
NASH
TGR5
Cd36
AMPK alpha
Multi-Enzymatic Cascade One-Pot Biosynthesis of 3 '-Sialyllactose Using Engineered Escherichia coli
期刊论文
MOLECULES, 2020
作者:
Li, Zhongkui
;
Ni, Zhijian
;
Chen, Xiangsong
;
Wang, Gang
;
Wu, Jinyong
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  |  
浏览/下载:46/0
  |  
提交时间:2020/11/30
multi-enzymes
biosynthesis
3 '-SL
cofactor regeneration
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed
期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2020, 页码: 9
作者:
Liu Changshui
;
Zang Kun
;
Li Shihao
;
Li Fuhua
;
Ma Qingiun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/09/22
thymidylate synthase (TS)
closed conformation
deoxyuridine monophosphate (dUMP)
thymidine monophosphate (TMP)
raltitrexed
Litopenaeus vannamei
Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 7
作者:
Weng, Zhiying
;
Xu, Guowei
;
Chen, Dingyuan
;
Yang, Yaqing
;
Song, Gao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/03/18
Adenylyl cyclases
Homology modeling
Consensus scoring
Molecular dynamics simulation
Virtual screening
Biological evaluation
Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity
期刊论文
TRANSLATIONAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 1, 页码: 215-226
作者:
Zhang, Yibing
;
Zhao, Yong
;
Ran, Yongwang
;
Guo, Jianyou
;
Cui, Haifeng
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/08/03
5 '-AMP-activated protein kinase
neurotoxicity
notoginsenoside R1
sevoflurane
sestrin-2
reactive oxygen species
Effects of suspended particular matters, excess PO43-, and salinity on phosphorus speciation in coastal river sediments
期刊论文
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2020
作者:
Zhao, Guoqiang
;
Sheng, Yanqing
;
Wang, Wenjing
;
Liu, Qunqun
;
Jiang, Ming
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2020/07/08
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