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上海药物研究所 [43]
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期刊论文 [202]
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2019 [211]
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Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity
期刊论文
ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 24, 页码: 15577-15584
作者:
Ding, Chunyong
;
Wang, Fengyang
;
Dang, Yijing
;
Xu, Zhiai
;
Li, Lingling
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:
Zhou, Yeheng
;
Sun, Wei
;
Peng, Jiale
;
Yan, Hui
;
Zhang, Li
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  |  
浏览/下载:14/0
  |  
提交时间:2020/03/18
Acetylcholinesterase
Drug design
N-acylhydrazone
Dementia
Copper-chelating
N-Benzylpiperidine
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
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  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Preparation of starch derivatives bearing urea groups and the evaluation of antioxidant, antifungal, and antibacterial activities
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 141, 页码: 1271-1279
作者:
Zhang, JJ
;
Mi, YQ
;
Sun, XQ
;
Chen, Y
;
Gu, GD
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  |  
浏览/下载:60/0
  |  
提交时间:2020/07/08
Bioactivities
Starch derivatives
Urea groups
Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells
期刊论文
REGENERATIVE BIOMATERIALS, 2019, 卷号: 6, 期号: 6, 页码: 361-371
作者:
Lei, Xiongxin
;
Gao, Jianping
;
Xing, Fangyu
;
Zhang, Yang
;
Ma, Ye
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  |  
浏览/下载:7/0
  |  
提交时间:2020/05/06
nano-hydroxyapatite
natural bone ceramic
collagen
scaffold
MC3T3-E1
osteoblasts
Synthesis and Biological Evaluation of Five-Atom-Linker-Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile
期刊论文
CHEMMEDCHEM, 2019, 页码: 11
作者:
Wu, Chunhui
;
Wang, Yu
;
Yang, Feipu
;
Shi, Wenqiang
;
Wang, Zhen
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
D-2
5-HT1A
5-HT2A
serotonin
SERT
PCP-induced hyperactivity
A value-added insight of reusing microplastic waste: Carrier particle in fluidized bed bioreactor for simultaneous carbon and nitrogen removal from septic wastewater
期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2019, 卷号: 151, 页码: 17
作者:
He, Xiaoqin
;
Li, Haibin
;
Zhu, Jesse
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  |  
浏览/下载:56/0
  |  
提交时间:2020/10/29
Recycled microplastics
Composite particles (CP)
Low C/N
Bacterial community structure
Energy intensity (EI)
Particle attrition
Nutrient fate
Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 期号: 21, 页码: 13646-13654
作者:
Ni, Jiabin
;
Nishonov, Bekzod
;
Pardaev, Azizbek
;
Zhang, Ao
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
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  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
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