Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones

doi:10.1021/acs.joc.9b01897

	Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones
	Ni, Jiabin 1,3; Nishonov, Bekzod 1,3; Pardaev, Azizbek 1,3; Zhang, Ao 1,2,3
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2019-11-01
卷号	84 期号:21 页码:13646-13654
ISSN号	0022-3263
DOI	10.1021/acs.joc.9b01897
通讯作者	Zhang, Ao(aozhang@simm.ac.cn)
英文摘要	A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This protocol involves C-C bond cleavage, beta-F elimination, and allylic coupling to form corresponding 2-fluoroallylic sulfones efficiently with Z-selectivity. Different substrates bearing diverse functional groups are tolerated. Moreover, this method is successfully used for the late-stage derivation of several bioactive molecules.
资助项目	National Program on Key Basic Research Project of China[2015CB910603-004] ; Chinese National NSF[81430080] ; Chinese National NSF[81773565]
WOS关键词	BIOLOGICAL EVALUATION ; DIFLUORINATED CYCLOPROPANES ; DESIGN ; FLUORINE ; POTENT ; AGENTS ; FLUOROOLEFINS ; DERIVATIVES ; INHIBITORS ; ANALOGS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000494562600039
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281927]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Ao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ni, Jiabin,Nishonov, Bekzod,Pardaev, Azizbek,et al. Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(21):13646-13654.
APA	Ni, Jiabin,Nishonov, Bekzod,Pardaev, Azizbek,&Zhang, Ao.(2019).Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones.JOURNAL OF ORGANIC CHEMISTRY,84(21),13646-13654.
MLA	Ni, Jiabin,et al."Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones".JOURNAL OF ORGANIC CHEMISTRY 84.21(2019):13646-13654.