QQ客服 官方微博 反馈留言

浏览/检索结果: 共37条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23 作者:  Zou, Yi;  Hu, Yue;  Ge, Shushan;  Zheng, Yingbo;  Li, Yuezhen 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 IDO1  Heme  T cell  Cancer immunotherapy  Virtual screening  Drug design  Molecular dynamics simulation   Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer 期刊论文 PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11 作者:  Wang Yuwei;  Tang Chunping;  Yao Sheng;  Lai Huanling;  Li Runze 收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 Non-small cell lung cancer  Natural product  Croton tiglium  Protein kinase C  Molecular modelling   Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi 收藏  |  浏览/下载：75/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives   Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989 作者:  Zhou, Fang;  Ding, Kang;  Zhou, Yiqing;  Liu, Yang;  Liu, Xiaoyan 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2 期刊论文 RSC ADVANCES, 2019, 卷号: 9, 期号: 61, 页码: 35904-35912 作者:  Ding, Lixia;  Wang, Lu;  Zou, Kun;  Li, Bo;  Song, Yunqing 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85 作者:  Zhan, Wenhu;  Che, Jinxin;  Xu, Lei;  Wu, Yizhe;  Hu, Xiaobei 收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01 Pyrazole-thiophene derivatives  Akt inhibitor  Antitumor   Designing of novel ERR gamma inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives 期刊论文 MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 10, 页码: 1661-1673 作者:  Li, Rui;  Du, Yongli;  Shen, Jingkang 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 ERR gamma inverse agonist  Molecular docking  3D-QSAR  CoMFA  CoMSIA   Discovery of betulinaldehyde as a natural ROR gamma t agonist 期刊论文 FITOTERAPIA, 2019, 卷号: 137, 页码: 8 作者:  Yang, Feng;  Zhang, Ruihan;  Ni, Dongxuan;  Luo, Xiaomin;  Chen, Shijie 收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01 ROR gamma t  Receptor agonist  Triterpenoids  Alpha screen  Molecular docking   Structural and functional studies of USP20 ZnF-UBP domain by NMR 期刊论文 PROTEIN SCIENCE, 2019, 卷号: 28, 期号: 9, 页码: 1606-1619 作者:  Yang, Yuanyuan;  Ding, Yiluan;  Zhou, Chen;  Wen, Yi;  Zhang, Naixia 收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 deubiquitinase  NMR  solution structure  USP20  ZnF-UBP domain   Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 9, 页码: 2599-2608 作者:  Li Yingjun;  Zhao Yue;  Jin Kun;  Gao Lixin;  Sheng Li 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 1,3,4-thiadiazolamide  carbazole  benzimidazole  synthesis  PTP1B inhibitor  molecular docking  density functional theory (DFT) study