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科研机构
上海药物研究所 [30]
内容类型
期刊论文 [30]
发表日期
2019 [30]
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发表日期:2019
专题:上海药物研究所
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Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 61, 页码: 35904-35912
作者:
Ding, Lixia
;
Wang, Lu
;
Zou, Kun
;
Li, Bo
;
Song, Yunqing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy
期刊论文
ACTA POLYMERICA SINICA, 2019, 卷号: 50, 期号: 11, 页码: 1156-1166
作者:
Gao, Jing
;
Wang, Wei-qi
;
Yu, Hai-jun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Nanosized drug delivery system
Tumor acidic microenvironment
Polymeric nanoparticles
Physiological barriers
Current trends in drug metabolism and pharmacokinetics
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144
作者:
Li, Yuhua
;
Meng, Qiang
;
Yang, Mengbi
;
Liu, Dongyang
;
Hou, Xiangyu
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs
Proteomic analysis of male rat nucleus accumbens, dorsal hippocampus and amygdala on conditioned place aversion induced by morphine withdrawal
期刊论文
BEHAVIOURAL BRAIN RESEARCH, 2019, 卷号: 372, 页码: 8
作者:
Guo, Liu-bin
;
Yu, Chuan
;
Ling, Qing-lan
;
Fu, Yu
;
Wang, Yu-jun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Morphine withdrawal
Aversive memories
Proteomics
Synaptic plasticity
Amygdala
Dorsal hippocampus
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16
作者:
He, Yulong
;
Dou, Huixia
;
Gao, Dingding
;
Wang, Ting
;
Zhang, Mingming
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Dual FABP4/5 inhibitor
Structure-based design
Lipolysis inhibition
Anti-inflammatory effects
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.
期刊论文
STEROIDS, 2019, 卷号: 149, 页码: 5
作者:
Jiang, Cheng-Shi
;
Ru, Tong
;
Huan, Xia-Juan
;
Miao, Ze-Hong
;
Guo, Yue-Wei
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Soft coral
Sinularia sp.
Ergostane
Antiproliferative activity
Apoptosis
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:
Wang, Yulan
;
Dai, Yang
;
Wu, Xiaowei
;
Li, Fei
;
Liu, Bo
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Folic acid and its metabolite codetermination for pharmacokinetics with circadian rhythms and evaluation of oral bioavailability
期刊论文
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2019, 页码: 10
作者:
Meng, Fanyue
;
Zhang, Guoqing
;
Wang, Caifen
;
Zhu, Rui
;
Li, Haiyan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
5-methyltetrahydrofolic acid
circadian rhythms
fasted plasma
folic acid
pharmacokinetics
Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP
期刊论文
EMBO JOURNAL, 2019, 页码: 18
作者:
Xu, Zhaowei
;
Zhang, Hainan
;
Zhang, Xingrun
;
Jiang, Hewei
;
Liu, Chengxi
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
c-di-GMP
CobB
diguanylate cyclase
negative feedback loop
protein acetylation
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