Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy

doi:10.11777/j.issn1000-3304.2019.19133

	Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy
	Gao, Jing 2,3; Wang, Wei-qi 1; Yu, Hai-jun 2,3
刊名	ACTA POLYMERICA SINICA
	2019-11-01
卷号	50 期号:11 页码:1156-1166
关键词	Nanosized drug delivery system Tumor acidic microenvironment Polymeric nanoparticles Physiological barriers
DOI	10.11777/j.issn1000-3304.2019.19133
通讯作者	Yu, Hai-jun(hjyu@simm.ac.cn)
英文摘要	The polymeric drug delivery systems (DDS) have showed promising potential for improving cancer therapy, which can lengthen the blood circulation and minimize the adverse effect of chemotherapeutics. Despite promising, the therapeutic performance of polymeric-based DDS is affected by a series of physiological barriers, including limited tumor accumulation, restricted tumor penetration, insufficient cellular uptake, and slow drug release inside the tumor cells. It has been well-investigated that there is an acidic microenvironment inside the solid tumors due to the abnormal glucose metabolism of tumor cells. Moreover, the subcellular organelles including endosome and lysosome display much lower acidic pH than that of cytosol. The extracellular and intracellular acidic microenvironments have thus been exploited as both a trigger and target for tumor-targeted drug delivery. In this review article, we summarized our recent advances in developing acid-responsive polymeric DDS by taking the advantage of the acidic microenvironment of tumor tissue and tumor cells. We particularly highlighted the acid-responsive chemical bonds and components employed for constructing the acid-activatable DDS. These acid-activatable nanovectors have been exploited for combating the physiological barriers by surface charge conversion, nanostructure dissociation, and ligand presentation. We also provided a perspective regarding of the challenges and opportunities about clinical translation of the stimuli-activatable DDS.
WOS关键词	GENE DELIVERY ; PHOTODYNAMIC THERAPY ; WORMLIKE MICELLES ; TUMOR PENETRATION ; LUNG-CANCER ; PH ; NANOPARTICLES ; RESISTANCE ; DESIGN ; SIRNA
WOS研究方向	Polymer Science
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000497774600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282029]
专题	中国科学院上海药物研究所
通讯作者	Yu, Hai-jun
作者单位	1.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Gao, Jing,Wang, Wei-qi,Yu, Hai-jun. Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy[J]. ACTA POLYMERICA SINICA,2019,50(11):1156-1166.
APA	Gao, Jing,Wang, Wei-qi,&Yu, Hai-jun.(2019).Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy.ACTA POLYMERICA SINICA,50(11),1156-1166.
MLA	Gao, Jing,et al."Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy".ACTA POLYMERICA SINICA 50.11(2019):1156-1166.