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科研机构
山东大学 [20]
生物物理研究所 [1]
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期刊论文 [20]
会议论文 [1]
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2019 [4]
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2016 [1]
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2014 [3]
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Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 13, 页码: 2771-2783
作者:
Chen, Chen
;
Nie, Yiming
;
Xu, Guangsen
;
Yang, Xinying
;
Fang, Hao
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/11
Apoptosis
Anticancer
Bcl-2/Mcl-1 dual inhibitor
Indomethacin
derivatives
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 181
作者:
Chen, Chen
;
Yang, Xinying
;
Fang, Hao
;
Hou, Xuben
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/11
8-Hydroxyquinoline
MMP-2/9 inhibitors
Anti-migration/invasion
Anti-angiogenesis
Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 21, 页码: 8653-8663
作者:
Li, Kangshuai
;
Hou, Xuben
;
Li, Ruirui
;
Bi, Wenxiang
;
Yang, Fan
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2019/12/11
allosteric regulation
enzyme inhibitor
enzyme
inhibitor
nuclear
magnetic resonance (NMR)
autoimmunity
lymphoid-specific tyrosine
phosphatase (LYP)
protein-tyrosine phosphatase nonreceptor type 22
(PTPN22)
tyrosine phosphatase inhibitor
WPD-loop
Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 8, 页码: 1122-1127
作者:
Liang, Tao
;
Hou, Xuben
;
Zhou, Yi
;
Yang, Xinying
;
Fang, Hao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
HDAC6
isoform-selective
2,4-imidazolinedione
antiproliferative
apoptosis
Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 11, 页码: 2331-2342
作者:
Hou, Xuben
;
Rooklin, David
;
Yang, Duxiao
;
Liang, Xiao
;
Li, Kangshuai
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1 beta production via suppressing the NF-kappa B pathway and ROS production
期刊论文
JOURNAL OF HEPATOLOGY, 2017, 卷号: 66, 期号: 4, 页码: 693-702
作者:
Yu, Xin
;
Lan, Peixiang
;
Hou, Xuben
;
Han, Qiuju
;
Lu, Nan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/12
Hepatitis B virus
Hepatitis B e antigens
NLRP3 inflammasome
IL-1
beta
Inflammasomes
Interleukin-1 beta
Reactive oxygen species
HBV Inhibits LPS-induced NLRP3 Inflammasome Activation and IL-1β Production via Suppressing NF-κB Pathway and ROS Production
会议论文
第十二届全国免疫学学术大会
作者:
Zhang Cai
;
Yu Xin
;
Hou Xuben
;
Han Qiuju
;
Zhang Jian
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/31
HBV
HBeAg
NLRP3 inflammasome
IL-1β
Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Hou, Xuben
;
Rooklin, David
;
Fang, Hao
;
Zhang, Yingkai
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 24, 页码: 7685-7693
作者:
Wan, Yichao
;
Wang, Junhua
;
Sun, Feng'e
;
Chen, Minglu
;
Hou, Xuben
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
Apoptosis
Bcl-2
Mcl-1
Pyrrolidine
Anti-tumor
Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 23, 页码: 7359-7365
作者:
Wang, Gang
;
Wang, Yutao
;
Wang, Lei
;
Han, Leiqiang
;
Hou, Xuben
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/17
Bcl-2
Imidazolidine-2,4-dione
Inhibitors
Antitumor
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