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科研机构
中国医学科学院 北京... [7]
内容类型
期刊论文 [7]
发表日期
2017 [2]
2016 [3]
2015 [1]
2014 [1]
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Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells
期刊论文
2017, 卷号: 7, 页码: 41862
作者:
Liu, Lu
;
Zhang, Na
;
Dou, Yueying
;
Mao, Genxiang
;
Bi, Chongwen
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Synthesis, Biological Evaluation, and Autophagy Mechanism of 12N-Substituted Sophoridinamines as Novel Anticancer Agents
期刊论文
2017, 卷号: 8, 期号: 2, 页码: 245-250
作者:
Bi, Chongwen
;
Zhang, Na
;
Yang, Peng
;
Ye, Cheng
;
Wang, Yanxiang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Sophoridinamine
anticancer
structure-activity relationship
autophagy
lysosomes
IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1 alpha and PERK signaling
期刊论文
2016, 卷号: 7, 期号: 17, 页码: 23860-23873
作者:
Zhang, Na
;
Bi, Chongwen
;
Liu, Lu
;
Dou, Yueying
;
Tang, Sheng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
sophoridinic acid
ER stress
apoptosis
hepatocellular carcinoma
CHOP
Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage
期刊论文
2016, 卷号: 9, 页码: 2805-2817
作者:
Zhao, Wuli
;
Zhang, Caixia
;
Bi, Chongwen
;
Ye, Cheng
;
Song, Danqing
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
topoisomerase inhibitor
topoisomerase 1
DNA breakage
sophoridinol
anticancer
apoptosis
cell cycle
Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents
期刊论文
2016, 卷号: 6, 期号: 3, 页码: 222-228
作者:
Bi, Chongwen
;
Ye, Cheng
;
Li, Yinghong
;
Zhao, Wuli
;
Shao, Rongguang
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/04
Sophoridinic derivatives
Synthesis
Structure activity relationship
Anticancer
Drug resistance
The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2 alpha by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation
期刊论文
2015, 卷号: 6, 期号: 35, 页码: 37871-37894
作者:
Zhao, Wuli
;
Jiang, Guohua
;
Bi, Chongwen
;
Li, Yangbiao
;
Liu, Jingbo
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/01/13
dual topoisomerase inhibitor
topoisomerase2 alpha
cardiotoxicity
DNA religation
enhancing strand cleavage
Synthesis and Biological Evaluation of Sophoridinol Derivatives as a Novel Family of Potential Anticancer Agents
期刊论文
2014, 卷号: 5, 期号: 11, 页码: 1225-1229
作者:
Bi, Chongwen
;
Zhang, Caixia
;
Li, Yinghong
;
Tang, Sheng
;
Wang, Shenggang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/13
Sophoridine
sophoridinol
structure-activity relationship
antiproliferative
drug resistance
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