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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
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2021 [3]
2020 [2]
2018 [3]
2016 [1]
2012 [1]
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Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020)
期刊论文
MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/11/04
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
Molecular Cancer, 2021, 卷号: 20, 期号: 1
作者:
Zhang,Tao
;
Qu,Rong
;
Chan,Shingpan
;
Lai,Mengzhen
;
Tong,Linjiang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
PI3K alpha inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 3
作者:
Xie, Qin
;
Chi, Shuaishuai
;
Fang, Yanfen
;
Sun, Yiming
;
Meng, Linghua
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
Integrative Proteomic Characterization of Human Lung Adenocarcinoma
期刊论文
CELL, 2020, 卷号: 182, 期号: 1, 页码: 245-+
作者:
Xu, Jun-Yu
;
Zhang, Chunchao
;
Wang, Xiang
;
Zhai, Linhui
;
Ma, Yiming
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/12/24
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer (NSCLC)
EGFR T790M
Small-molecule inhibitor
Drug resistance
Ack1
Discovery of JND3229 as a New EGFR(C797S) Mutant Inhibitor with In Vivo Monodrug Efficacy
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 11, 页码: 1123-1127
作者:
Lu, Xiaoyun
;
Zhang, Tao
;
Zhu, Su-Jie
;
Xun, Qiuju
;
Tong, Lingjiang
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2019/01/08
EGFR(C797s)
Clinical resistance
Fourth-generation nhibitors
Monodrug efficacy
Identification of recurrent USP48 and BRAF mutations in Cushing's disease
期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9
作者:
Chen, Jianhua
;
Jian, Xuemin
;
Deng, Siyu
;
Ma, Zengyi
;
Shou, Xuefei
收藏
  |  
浏览/下载:117/0
  |  
提交时间:2019/01/08
EZH2 inhibitors abrogate upregulation of H3K27me3 by CDK9 inhibitors and potentiate its antitumor activity in DLBCL
期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2
作者:
Xie, Shao
;
Wei, Fan
;
Sun, Yiming
;
Gao, Yinglei
;
Ding, Jian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
dw10075anovelselectiveandsmallmoleculeinhibitorofvegfrexhibitsantitumoractivitiesbothinvitroandinvivo
期刊论文
actapharmacologicasinica, 2016, 卷号: 37, 期号: 3, 页码: 398
作者:
Ll Mengyuan
;
Lv Yongcong
;
Tong Linjiang
;
Peng Ting
;
Qu Rong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
DW10075
VEGF/VEGF receptor inhibitor
Antitumor
Angiogenesis
U87-MG human glioblastoma
Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G_2-M arrest and apoptosis in HeLa cells
期刊论文
Acta Pharmacologica Sinica, 2012, 卷号: 33, 期号: 3, 页码: 407
作者:
Ma Yiming
;
Zhou Yubo
;
Xie Chuanming
;
Chen Dongmei
;
Li Jia
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
ACTIVATED PROTEIN-KINASE
TUBULIN-BINDING AGENT
IN-VIVO
ANTIMICROBIAL ACTIVITY
ANTICANCER ACTIVITY
CYCLE ARREST
CANCER-CELLS
DERIVATIVES
INHIBITOR
RESISTANT
anticancer drug
6-chloro-4-(methoxyphenyl) coumarin
cell cycle arrest
microtubule depolymerization
apoptosis
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