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科研机构
上海药物研究所 [8]
合肥物质科学研究院 [5]
海洋研究所 [1]
烟台海岸带研究所 [1]
内容类型
期刊论文 [15]
发表日期
2021 [15]
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Clinical outcomes of lung adenocarcinoma patients harboring uncommon epidermal growth factor receptor (EGFR) mutations treated with EGFR-tyrosine kinase inhibitors (TKIs)
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2021
作者:
Si, Jinfei
;
Gu, Xiaodong
;
Wang, Wenxian
;
Ying, Shenpeng
;
Song, Zhengbo
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/02/14
Epidermal growth factor receptor (EGFR)
uncommon mutation
compound mutation
double uncommon mutation
lung adenocarcinoma (lung AC)
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 7, 页码: 20
作者:
Zhou, Zikai
;
He, Guiqin
;
Zhang, Xiaoyun
;
Lv, Xin
;
Zhang, Xiaolin
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2021/11/04
Liquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202
作者:
Li, Na
;
Mao, Weimin
;
Gao, Yun
;
Wang, Ding
;
Song, Zhengbo
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  |  
浏览/下载:47/0
  |  
提交时间:2021/08/31
Lung cancer
EGFR-TKI
Resistance
Pleural effusion
Metabolomics
Biomarker
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Transcriptome Regulation by Oncogenic ALK Pathway in Mammalian Cortical Development Revealed by Single-Cell RNA Sequencing
期刊论文
CEREBRAL CORTEX, 2021, 卷号: 31, 期号: 8, 页码: 3911-3924
作者:
Mao, Rui
;
Zhang, Xiaoyun
;
Kong, Youyong
;
Wu, Shanshan
;
Huo, Hai-qin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
anaplastic lymphoma kinase
cerebral organoid
neurodevelopment
neural progenitor cell
single-cell RNA sequencing
Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 219, 页码: 12
作者:
Rao, Danni
;
Li, Heng
;
Ren, Xuelian
;
Sun, Yaoliang
;
Wen, Cuiyun
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
Zeta-chain associated protein kinase 70 kDa (ZAP-70)
Covalent inhibitor
T cell
Autoimmune diseases
The correlation between the abundance of EGFR T790M mutation and osimertinib response in advanced non-small cell lung cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:
Pan, Guoqiang
;
Chen, Kaiyan
;
Yu, Xiaoqing
;
Sheng, Jiamin
;
Fan, Yun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/01
Non-small cell lung cancer (NSCLC)
T790M abundance
droplet digital PCR (ddPCR)
next generation sequencing (NGS)
osimertinib
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:
Qi, Si-Min
;
Dong, Jinyun
;
Xu, Zhi-Yuan
;
Cheng, Xiang-Dong
;
Zhang, Wei-Dong
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/06/15
PROTAC
E3 ubiquitin ligase
protein degradation
ubiquitin-proteasome system
cancer therapy
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