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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Structure-activity relationship of surface hydroxyl groups during NO2 adsorption and transformation on TiO2 nanoparticles
期刊论文
ENVIRONMENTAL SCIENCE-NANO, 2017, 卷号: 4, 期号: 12, 页码: 2388-2394
作者:
Ma, Jinzhu
;
He, Guangzhi
;
Liu, Chang
;
Ma, Qingxin
;
He, Hong
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  |  
浏览/下载:225/0
  |  
提交时间:2018/07/25
Surface Structure
Ceria
Atomic Layer Reversal
Aberration-corrected Tem
First-principles Calculations
The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 卷号: 105, 页码: 686-692
作者:
Jin, Weihua
;
Zhang, Wenjing
;
Liu, Ge
;
Yao, Jianting
;
Shan, Tifeng
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  |  
浏览/下载:50/0
  |  
提交时间:2019/07/15
Heteropolysaccharide
Anti-tumor activity
Sargassum thunbergii
Structure-activity relationship
Three conserved regions in baculovirus sulfhydryl oxidase p33 are critical for enzymatic activity and function
期刊论文
Journal of virology, 2017, 卷号: 91, 期号: 23, 页码: 16
作者:
Kuang, Wenhua
;
Zhang, Huanyu
;
Wang, Manli
;
Zhou, Ning-Yi
;
Deng, Fei
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  |  
浏览/下载:64/0
  |  
提交时间:2019/05/08
Mnpv
Odv
P33
Snpv
Baculovirus
Crystal structure
Disulfide bond
Occlusion body (ob)
Oral infection
Sulfhydryl oxidase
Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents
期刊论文
PHARMAZIE, 2017, 卷号: 72, 期号: 12, 页码: 707-713
作者:
Hu, Yuanyuan
;
Ruan, Wenchen
;
Gao, Anhui
;
Zhou, Yubo
;
Gao, Lixin
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133
作者:
Jin, Jiyu
;
Huang, Suling
;
Wang, Lei
;
Leng, Ying
;
Lu, Wei
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  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
adipose triglyceride lipase inhibitors
Atglistatin
structure-activity relationship
thiourea
Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266
作者:
Zheng, Qiangang
;
Tang, Shuai
;
Fu, Xianlei
;
Chen, Ziqi
;
Ye, Yan
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Indane amide
Structure-based rational design
Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336
作者:
Fu, Yan
;
Tang, Shuai
;
Su, Yi
;
Lan, Xiaojing
;
Ye, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Cyclin-dependent kinase
CDK inhibitor
Structure-activity relationship
In vitro and in vivo profiling
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112
作者:
Ji, Yue-Yang
;
Lin, Sen-Dong
;
Wang, Yu-Jie
;
Su, Ming-Bo
;
Zhang, Wei
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  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Tranylcypromine
LSD1
Stereoselective cyclopropanation
Chiral synthesis
MAO-A
MAO-B
Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES, 2017, 卷号: 62, 期号: 0, 页码: 68-83
作者:
Mao, Li
;
Zhu, Benzhan
;
Shen, Chen
;
Gao, Huiying
;
Zhu, Liya
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  |  
浏览/下载:25/0
  |  
提交时间:2018/07/26
Halogenated Phenols
Halogenated Quinoid Intermediates
Semiquinone Radical
Hydroxyl Radicals
Fenton Reaction
Chemiluminescene Method
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