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科研机构
上海药物研究所 [13]
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期刊论文 [13]
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2021 [1]
2020 [2]
2018 [1]
2017 [1]
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Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Molecular mechanisms of fentanyl mediated beta-arrestin biased signaling
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2020, 卷号: 16, 期号: 4, 页码: 24
作者:
de Waal, Parker W.
;
Shi, Jingjing
;
You, Erli
;
Wang, Xiaoxi
;
Melcher, Karsten
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 3, 页码: 482-491
作者:
Cheng, Jian-xin
;
Cheng, Tao
;
Li, Wei-hua
;
Liu, Gui-xia
;
Zhu, Wei-liang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
G-protein-coupled receptors
opioid receptors
subtype selectivity
molecular dynamics
"message-address-efficacy" hypothesis
JDTic
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 4, 页码: 766-776
作者:
Li, Wei
;
Long, Jian-Dong
;
Qian, Yuan-Yuan
;
Long, Yu
;
Xu, Xue-Jun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
kappa-opioid receptor
mu-opioid receptor
nepenthones
4,5-epoxymorphinans
pharmacological heterogeneity
structure activity relationship
binding structure
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
期刊论文
NATURE COMMUNICATIONS, 2016, 卷号: 7
作者:
Du, Changsheng
;
Duan, Yanhui
;
Wei, Wei
;
Cai, Yingying
;
Chai, Hui
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 2, 页码: 482-491
作者:
Wang, Wei-Sheng
;
Chen, Zhong-Guo
;
Liu, Wen-Tao
;
Chi, Zhi-Qiang
;
He, Ling
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
drug withdrawal
extinction
amygdala
hippocampal
Synthesis and SAR Study of Opioid Receptor Ligands: Mono- and Bis-Indolomorphinans
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2009, 卷号: 74, 期号: 4, 页码: 335-342
作者:
Li, Fuying
;
Yin, Chenlei
;
Chen, Jie
;
Liu, Jinggen
;
Xie, Xin
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
indole
morphinans scaffold
opioid receptor
structure-activity relationships
Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment
期刊论文
CELL RESEARCH, 2007, 卷号: 17, 期号: 8, 页码: 689-700
作者:
Chen, Xiao-Lan
;
Lu, Gang
;
Gong, Ying-Xia
;
Zhao, Liang-Cai
;
Chen, Jie
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
hippocampus
glucose
morphine
dependence
learning and memory
Colocalization of phosphorylated CREB with calcium/calmodulin-dependent protein kinase IV in hippocampal neurons induced by ohmfentanyl stereoisomers
期刊论文
BRAIN RESEARCH, 2004, 卷号: 1024, 期号: 1-2, 页码: 25-33
作者:
Gao, C
;
Chen, LW
;
Tao, YM
;
Chen, J
;
Xu, XJ
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
ohmfentanyl stereoisomer
cAMP response element-binding protein
Ca2+/calmodulin-dependent protein kinase IV
hippocampal neuron
opioids dependence
phosphorylation
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