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科研机构
上海药物研究所 [16]
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期刊论文 [16]
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2021 [1]
2020 [2]
2019 [1]
2018 [4]
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A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+
作者:
Liu, Zhiwei
;
Liu, Yingluo
;
Qian, Lili
;
Jiang, Shangwen
;
Gai, Xiameng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/12/01
Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2020, 卷号: 7, 期号: 13, 页码: 1606-1615
作者:
Xu, Ke
;
Man, Qingmin
;
Zhang, Yang
;
Guo, Jia
;
Liu, Yichu
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:
Li, Zhiqiang
;
Li, Xinzhi
;
Su, Ming-Bo
;
Gao, Li-Xin
;
Zhou, Yu-Bo
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 1, 页码: 27-33
作者:
Wang, Lei
;
Qiao, Guan-Hua
;
Hu, Hai-Ning
;
Gao, Zhao-Bing
;
Nan, Fa-Jun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
KCNQ channel
retigabine
subtype selectivity
agonist
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
期刊论文
ONCOGENESIS, 2018, 卷号: 7
作者:
Chen, Wei
;
Zhang, Hao
;
Chen, Zhifeng
;
Jiang, Hao
;
Liao, Liping
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2019/01/08
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 302-310
作者:
Zhu, Mao-rong
;
Du, Dao-hai
;
Hu, Jun-chi
;
Li, Lian-chun
;
Liu, Jing-qiu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 817-842
作者:
Zhou, Pengfei
;
Liang, Yuru
;
Zhang, Hao
;
Jiang, Hao
;
Feng, Kechang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 302
作者:
Zhu Maorong
;
Du Daohai
;
Hu Junchi
;
Li Lianchun
;
Liu Jingqiu
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2020/07/01
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
Glycoengineering and glycosite-specific labeling of serum IgGs from various species
期刊论文
CARBOHYDRATE RESEARCH, 2017, 卷号: 446, 页码: 32-39
作者:
Guo, Weilai
;
Tang, Feng
;
Qin, Ken
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
Chemoenzymatic glycoengineering
Serum IgG
Glycosite-specific IgG labeling
Rabbit IgG
Mouse IgG
Goat IgG
Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 9, 页码: 2003-2009
作者:
Sun, Zhongya
;
Zhang, Hao
;
Chen, Zhifeng
;
Xie, Yiqian
;
Jiang, Hao
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
BRD4 inhibitor
High-throughput screening
Crystallography
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