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A Pathway-Specific Polygenic Risk Score Is Associated with Tau Pathology and Cognitive Decline
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2022, 卷号: 85, 期号: 4, 页码: 1745-1754
作者:
Sun, Yuqing
;
Wang, Meng
;
Zhao, Yuxin
;
Hu, Ke
;
Liu, Yong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/06
Alzheimer's disease
cognitive function genetic risk scores
pathway
tau
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:
Xiong, Zhaoping
;
Jeon, Minji
;
Allaway, Robert J.
;
Kang, Jaewoo
;
Park, Donghyeon
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/11/04
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
期刊论文
Journal of Neuroinflammation, 2021, 卷号: 18, 期号: 1
作者:
Sun,Xiao-ying
;
Li,Ling-jie
;
Dong,Quan-Xiu
;
Zhu,Jie
;
Huang,Ya-ru
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/31
Alzheimer’s disease
Tau pathology
Neurofibrillary tangles
Neuroinflammation
Synapse loss
Rutin
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease
期刊论文
JOURNAL OF NEUROINFLAMMATION, 2021, 卷号: 18, 期号: 1, 页码: 14
作者:
Sun, Xiao-ying
;
Li, Ling-jie
;
Dong, Quan-Xiu
;
Zhu, Jie
;
Huang, Ya-ru
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/31
Alzheimer's disease
Tau pathology
Neurofibrillary tangles
Neuroinflammation
Synapse loss
Rutin
Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 卷号: 142
作者:
Li, Xiaowei
;
Yang, Yu
;
Zhao, Hengzhi
;
Zhu, Tian
;
Yang, Zhihui
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  |  
浏览/下载:25/0
  |  
提交时间:2020/11/26
MAPT rs242557 variant is associated with hippocampus tau uptake on F-18-AV-1451 PET in non-demented elders
期刊论文
AGING-US, 2019, 卷号: 11, 期号: 3
作者:
Greig-Custo, Maria T.
;
Shen, Xue-Ning
;
Miao, Dan
;
Li, Jie-Qiong
;
Tan, Chen-Chen
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/12/05
tauopathy
MAPT
hippocampus
F-18-AV-1451 PET
non-demented
Alzheimer's disease
Release of methylene blue from graphene oxide-coated electrospun nanofibrous scaffolds to modulate functions of neural progenitor cells
期刊论文
Acta biomaterialia, 2019, 卷号: 88, 页码: 346-356
作者:
Wang Lina[1]
;
Liu Xiaoyun[2]
;
Fu Jiqiang[3]
;
Ning Xinyu[4]
;
Zhang Mengxin[5]
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/04/22
Graphene oxide
Methylene blue
Nanofibrous scaffold
Neural progenitor cells
Tauopathy
Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
期刊论文
CURRENT ALZHEIMER RESEARCH, 2019, 卷号: 16, 期号: 8, 页码: 710-722
作者:
Sun, Xiao-Ying
;
Dong, Quan-Xiu
;
Zhu, Jie
;
Sun, Xun
;
Zhang, Li-Fan
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/12/02
Resveratrol
Alzheimer's disease
tau
oligomer
neuroinflammation
synapse loss
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia
期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
作者:
Ji, Mei
;
Xie, Xi-xiu
;
Liu, Dong-qun
;
Yu, Xiao-lin
;
Zhang, Yue
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2018/07/17
Alzheimer's Disease
Frontotemporal Dementia
Hepatitis b Core Protein
Truncated Tau
Neurofibrillary Tangles
Virus-like Particles (Vlps)
Vaccine
Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 45
作者:
Weismiller, Hilary A.
;
Murphy, Rachel
;
Wei, Guanghong
;
Ma, Buyong
;
Nussinov, Ruth
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
Tau protein (Tau)
amyloid
conformational change
Alzheimer disease
tauopathy
electron paramagnetic resonance (EPR)
fibril
protein aggregation
prion
protein structure
seeding barrier
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