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Notch pathway inhibition using DAPT, a gamma-secretase inhibitor (GSI), enhances the antitumor effect of cisplatin in resistant osteosarcoma
期刊论文
MOLECULAR CARCINOGENESIS, 2019, 卷号: 58, 期号: 1
作者:
Dai, Guo
;
Deng, Shuang
;
Guo, Weichun
;
Yu, Ling
;
Yang, Jian
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
cancer stem cell
chemoresistance
combination therapy
Notch signaling pathway
osteosarcoma (OS)
Alzheimer's disease hypothesis and related therapies
期刊论文
TRANSLATIONAL NEURODEGENERATION, 2018, 卷号: 7
作者:
Du, Xiaoguang
;
Wang, Xinyi
;
Geng, Meiyu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Alzheimer's disease
complicated disease
anti-AD drugs
Hypothesis about AD
IL6 blockade potentiates the anti-tumor effects of gamma-secretase inhibitors in Notch3-expressing breast cancer
期刊论文
CELL DEATH AND DIFFERENTIATION, 2018, 卷号: 25, 期号: 2
作者:
Wang, Dong
;
Xu, Jiahui
;
Liu, Bingjie
;
He, Xueyan
;
Zhou, Lei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Gamma secretase dependent release of the CD44 cytoplasmic tail upregulates IFIl 6 in cd44 tumor cells, MEFs and macrophages
期刊论文
PLOS ONE, 2018, 卷号: Vol.13 No.12
作者:
Herrlich, Peter
;
Ruschel, Anne
;
Gereke, Marcus
;
Minnich, Kerstin
;
Li, Yong
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  |  
浏览/下载:8/0
  |  
提交时间:2019/04/24
Cervical Cancer Cell Growth, Drug Resistance, and Epithelial-Mesenchymal Transition Are Suppressed by gamma-Secretase Inhibitor RO4929097
期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24
作者:
Wang, Lu
;
Dai, Guo
;
Yang, Jian
;
Wu, Wanrong
;
Zhang, Wei
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Epithelial-Mesenchymal Transition
Receptors, Notch
Uterine Cervical Neoplasms
gamma-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2018, 卷号: 142, 期号: 5
作者:
Mao, Liang
;
Zhao, Zhi-Li
;
Yu, Guang-Tao
;
Wu, Lei
;
Deng, Wei-Wei
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
notch1
head and neck squamous cell carcinoma
knockout mouse
immune checkpoint
myeloid-derived suppressor cell
tumour-associated macrophage
regulatory T cell
Defining the minimum substrate and charge recognition model of gamma-secretase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta (A beta)
amyloid precursor protein (APP)
C99, gamma-secretase
minimum substrate
Notch protein
recognition model
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 38, 页码: 15826-15837
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Harikumar, Kaleeckal G.
;
Miller, Laurence J.
;
Melcher, Karsten
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2017, 卷号: 15, 期号: 9, 页码: 641-652
作者:
Liu Qin
;
Wang Shun-Chun
;
Ding Kan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Polysaccharides
Traditional Chinese medicine
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