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期刊论文 [23]
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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
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浏览/下载:33/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
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  |  
浏览/下载:92/0
  |  
提交时间:2020/07/01
Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 83, 页码: 9
作者:
Pan, Chenling
;
Meng, Hao
;
Zhang, Shuqun
;
Zuo, Zhili
;
Shen, Yuehai
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  |  
浏览/下载:24/0
  |  
提交时间:2020/03/18
delta opioid receptor agonists
3D-QSAR
Homology modeling
Molecular dynamics simulation
Molecular docking
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 4, 页码: 766-776
作者:
Li, Wei
;
Long, Jian-Dong
;
Qian, Yuan-Yuan
;
Long, Yu
;
Xu, Xue-Jun
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  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
kappa-opioid receptor
mu-opioid receptor
nepenthones
4,5-epoxymorphinans
pharmacological heterogeneity
structure activity relationship
binding structure
Discovery of Potent and Selective Agonists of delta Opioid Receptor by Revisiting the "Message-Address" Concept
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 7, 期号: 4, 页码: 391-396
作者:
Shen, Qing
;
Qian, Yuanyuan
;
Huang, Xiaoqin
;
Xu, Xuejun
;
Li, Wei
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
delta opioid receptor
agonist
affinity
selectivity
molecular docking
Discovery of Potent and Selective Agonists of delta Opioid Receptor by Revisiting the "Message-Address" Concept
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 7, 期号: 4
作者:
Shen, Qing
;
Qian, Yuanyuan
;
Huang, Xiaoqin
;
Xu, Xuejun
;
Li, Wei
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
delta opioid receptor
agonist
affinity
selectivity
molecular docking
Structural Feature Studies on Spiropiperidine Analogues as Agonists of Delta Opioid Receptors
期刊论文
progress in biochemistry and biophysics, 2013, 卷号: 40, 期号: 7, 页码: 668-677
作者:
Gao Wei-Min
;
Li Yan
;
Zhang Shu-Wei
;
Yang Ling
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  |  
浏览/下载:21/0
  |  
提交时间:2015/11/09
N-substituted spiropiperidine analogues
DOR agonist
3D-QSAR
CoMFA
CoMSIA
Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons
期刊论文
NEUROSCIENCE BULLETIN, 2012, 卷号: 28, 期号: 2, 页码: 121-130
作者:
Zhang, X
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  |  
浏览/下载:21/0
  |  
提交时间:2013/06/04
DORSAL-ROOT GANGLIA
PROTEIN-COUPLED RECEPTORS
DENSE-CORE VESICLES
RAT SPINAL-CORD
MORPHINE-TOLERANCE
MESSENGER-RNAS
KNOCKOUT MICE
AUTORADIOGRAPHIC LOCALIZATION
PHYSICAL-DEPENDENCE
PERIPHERAL AXOTOMY
Interaction and regulatory functions of mu- and delta-opioid receptors in nociceptive afferent neurons
期刊论文
NEUROSCIENCE BULLETIN, 2012, 卷号: 28, 期号: 2, 页码: 121-130
作者:
Zhang, X
;
Bao, L
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浏览/下载:14/0
  |  
提交时间:2015/07/22
peripheral nervous system
opioid receptor
nociceptive pathways
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