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科研机构
上海药物研究所 [13]
复旦大学上海医学院 [5]
北京大学 [3]
上海神经科学研究所 [3]
厦门大学 [2]
上海有机化学研究所 [2]
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期刊论文 [33]
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(-)-Naringenin 4’,7-Dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain Through Inhibition of Multiple Channels
期刊论文
Molecules, 2022, 卷号: 5, 期号: 27, 页码: 1735
作者:
Ru-Rong Gu
;
Xian-Hua Meng
;
Yin Zhang
;
Hai-Yan Xu
;
Li Zhan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/30
(-)-Naringenin 40,7-dimethyl ether
analgesic candidate
mechanism study
delayed rectifier potassium currents
ion channels
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
Serotonin type-1D receptor stimulation of A-type K+ channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons
期刊论文
CELLULAR SIGNALLING, 2016, 卷号: 28, 期号: 8, 页码: 979-988
作者:
Zhao, XY
;
Zhang, Y
;
Qin, WJ
;
Cao, JP
;
Zhang, Y
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/09/14
DORSAL-ROOT GANGLION
KV4.2 POTASSIUM CHANNEL
BETA-GAMMA-SUBUNITS
NEUROPATHIC PAIN
SENSORY NEURONS
ENHANCED EXCITABILITY
INFLAMMATORY PAIN
MELANOMA-CELLS
ACTIVATION
MODULATION
VEGF ATTENUATED INCREASE OF OUTWARD DELAYED-RECTIFIER POTASSIUM CURRENTS IN HIPPOCAMPAL NEURONS INDUCED BY FOCAL ISCHEMIA VIA PI3-K PATHWAY
期刊论文
NEUROSCIENCE, 2015, 卷号: 298
作者:
Wu, K. W.
;
Yang, P.
;
Li, S. S.
;
Liu, C. W.
;
Sun, F. Y.
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/19
vascular endothelial growth factor
middle cerebral artery occlusion
patch clamp
hippocampal slice
potassium channel
stroke
Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents
期刊论文
nature communications, 2014
Yang, Yi-Mei
;
Wang, Wei
;
Fedchyshyn, Michael J.
;
Zhou, Zhuan
;
Ding, Jiuping
;
Wang, Lu-Yang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2015/11/11
TERM SYNAPTIC PLASTICITY
SHAKER K+ CHANNELS
TRANSMITTER RELEASE
ACTION-POTENTIALS
GATING CURRENTS
HELD SYNAPSE
DELAYED-RECTIFIER
PURKINJE NEURONS
IONIC CURRENTS
ACTIVATION
RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties
期刊论文
HEART RHYTHM, 2013, 卷号: 10, 期号: [db:dc_citation_issue], 页码: 128-136
作者:
Lu, Xiaoli
;
Yang, Xi
;
Huang, Xiaoyan
;
Huang, Chen
;
Sun, Huan Huan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
Rapidly activating delayed rectifier potassium current
RNA interference
Gene therapy
Long QT syndrome
Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 9, 页码: 1176-1186
作者:
Bai, Dong-lu
;
Chen, Wei-zhou
;
Bo, Yun-xin
;
Dong, Yue-li
;
Kang, Ai-li
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
sulcardine
sulcardine sulfate
changrolin
heart
arrhythmias
aconitine
ouabain
sodium current
L-type calcium current
Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 6, 页码: 728-736
作者:
Li, Ping
;
Sun, Hai-feng
;
Zhou, Ping-zheng
;
Ma, Chao-ying
;
Hu, Guo-yuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
dofetilide
DC031050
class III antiarrhythmic agent
hERG
KCNQ
Kv1.2
delayed rectifier potassium current
Hypericin prolongs action potential duration in hippocampal neurons by acting on K plus channels
期刊论文
http://dx.doi.org/10.1111/j.1476-5381.2009.00513.x, 2010
Wang, Y.
;
Shi, X.
;
Qi, Z.
;
戚智
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
NEUROTRANSMITTER RELEASE
ANTIDEPRESSANT ACTIVITY
POTASSIUM CURRENTS
CA2+ CHANNELS
PERFORATUM
MEMBRANE
BACKPROPAGATION
DEPRESSION
HYPERFORIN
CALCIUM
Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons
期刊论文
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2009, 卷号: 27, 期号: 3, 页码: 338-344
Liao, Chun-yang
;
Cui, Lin
;
Zhou, Qun-fang
;
Duan, Shu-min
;
Jiang, Gui-bin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2015/08/07
Perfluorooctane sulfonate (PFOS)
Neurotoxicity
Potassium channel
Sodium channel
Glutamate-activated current
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