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Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Structural Basis for the Inhibition of the Autophosphorylation Activity of HK853 by Luteolin
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 5, 页码: 11
作者:
Jiang, Ling
;
Liu, Yixiang
;
Liu, Maili
;
Li, Conggang
;
Luo, Liang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/06/24
two-component system
histidine kinase
luteolin
ATP
NMR
molecular docking
inhibition
Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 84, 页码: 312-321
作者:
Chu, Pengfei
;
He, Libo
;
Zhu, Denghui
;
Chen, Liangming
;
Huang, Rong
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/07/01
Grass carp
IRAK-M
Innate immune
Subcellular localisation
MyD88
Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors
期刊论文
Letters in Drug Design & Discovery, 2019, 卷号: Vol.16 No.2, 页码: 102-110
作者:
Min Zou
;
Bo Jin
;
Yanrong Liu
;
Huiping Chen
;
Zhuangli Zhang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/13
4-Aminoquinazoline
non-covalent
inhibitors
antiproliferative
activity
structure-activity
relationships
autophosphorylation
Western
blot
analysis
Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors
期刊论文
Letters in Drug Design & Discovery, 2019, 卷号: Vol.16 No.2, 页码: 102-110
作者:
Zou, Min
;
Jin, Bo
;
Liu, Yanrong
;
Chen, Huiping
;
Zhang, Zhuangli
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
4-Aminoquinazoline
Western
blot
analysis
antiproliferative
activity
autophosphorylation
non-covalent
inhibitors
structure-activity
relationships
Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors
期刊论文
Letters in Drug Design & Discovery, 2019, 卷号: Vol.16 No.2, 页码: 102-110
作者:
Min Zou
;
Bo Jin
;
Yanrong Liu
;
Huiping Chen
;
Zhuangli Zhang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/13
4-Aminoquinazoline
non-covalent
inhibitors
antiproliferative
activity
structure-activity
relationships
autophosphorylation
Western
blot
analysis.
DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 20, 期号: 4, 页码: 3609-3616
作者:
Han, Yang
;
Jin, Feng
;
Xie, Ying
;
Liu, Yike
;
Hu, Sai
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/27
parylation
double strand break repair
non-homologous end joining repair
autophosphorylation
Two Arabidopsis Receptor-like Cytoplasmic Kinases SZE1 and SZE2 Associate with the ZAR1-ZED1 Complex and Are Required for Effector-Triggered Immunity
期刊论文
MOLECULAR PLANT, 2019, 卷号: 12, 期号: 7, 页码: 967-983
作者:
Liu, Cheng
;
Cui, Dayong
;
Zhao, Jingbo
;
Liu, Na
;
Wang, Bo
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/01/06
Arabidopsis
RLCK
SZE-ZAR1-ZED1 complex
HopZ1a
immune response
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