CORC

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CORC

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Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:  Zhang, Rui;  Li, Heng;  Zhang, Xianglei;  Li, Jian;  Su, Haixia
收藏  |  浏览/下载：22/0  |  提交时间：2021/05/24
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun
收藏  |  浏览/下载：68/0  |  提交时间：2020/12/24
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/01
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2209-2226
作者:  Li, Heng;  Fan, Chen;  Feng, Chunlan;  Wu, Yanwei;  Lu, Huimin
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593
作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
收藏  |  浏览/下载：137/0  |  提交时间：2019/06/28
The effect of CPAP and PDE5i on erectile function in men with obstructive sleep apnea and erectile dysfunction: A systematic review and meta-analysis 期刊论文
Sleep Medicine Reviews, 2019, 卷号: 48
作者:  Li Z.;  Fang Z.;  Xing N.;  Zhu S.;  Fan Y.
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/11
Comparison of the Full-Length and 152~528 Truncate of Human Cyclic Nucleotide Phosphodiesterase 4B2 for the Characterization of Inhibitors. 期刊论文
Combinatorial chemistry & high throughput screening, 2019
作者:  Xiang Zhang;  Shu He;  Xiaolei Hu;  Jing Wu;  Xinpeng Li
收藏  |  浏览/下载：19/0  |  提交时间：2019/12/17
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:  Li, Heng;  Zuo, Jianping;  Tang, Wei
收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08

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