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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:
Liang, Xiaofei
;
Wang, Chun
;
Wang, Beilei
;
Liu, Juan
;
Qi, Shuang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/23
CSF1R inhibitor
Kinase inhibitor
Macrophage polarization
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Synthesis of fused-tetrahydropyrimidines: one-pot methylenation-cyclization utilizing two molecules of CO2
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 卷号: 18, 期号: 35
作者:
Zhao, Yulei
;
Guo, Xuqiang
;
Du, Yulan
;
Shi, Xinrui
;
Yan, Shina
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/11/25
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 5, 页码: 748-759
作者:
Guo, Shuang
;
Xu, Mingshuo
;
Guo, Qi
;
Zhu, Fuqiang
;
Jiang, Xiangrui
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Nucleoside
Double prodrug
Phosphoramidate
Anti-HCV
Pyrazine
Stereoselective N-glycosylation with N-4-acyl cytosines and efficient synthesis of gemcitabine
期刊论文
TETRAHEDRON, 2019, 卷号: 75, 期号: 9, 页码: 1203-1213
作者:
Liu, Tongchao
;
Tang, Jiadeng
;
Liang, Jianpeng
;
Chen, Yabin
;
Wang, Xiaowen
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Stereoselective
N-glycosylation
N-4-acyl cytosine
Nucleoside
Gemcitabine
A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 4, 页码: 17
作者:
Shang, Ruofeng
;
Fu, Yunxing
;
Liu, Yu
;
Yi, Yunpeng
;
Liang, Jianping
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2019/11/10
DPTM
HPLC-MS
MS
pharmacokinetics
distribution
excretion
Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 169-182
作者:
Pingxian Liu
;
Yunxiang Tang
;
Zhiyong Liu
;
Youfu Luo
;
Tao Yang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/04/24
Antimycobacterial
Ceritinib
Pyrimidine
derivatives
Dihydrofolate
reductase
inhibitors
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