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上海药物研究所 [3]
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兰州大学 [2]
四川大学 [2]
山东大学 [2]
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期刊论文 [18]
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A unique intra-molecular fidelity-modulating mechanism identified in a viral rna-dependent rna polymerase
期刊论文
Nucleic acids research, 2018, 卷号: 46, 期号: 20, 页码: 10840-10854
作者:
Liu, Weichi
;
Shi, Xiaoling
;
Gong, Peng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/05/08
Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1)
期刊论文
FRONTIERS IN MICROBIOLOGY, 2017, 卷号: 8
作者:
Yang, Na
;
Sun, Chaomin
;
Zhang, Lixin
;
Liu, Jianguo
;
Song, Fuhang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2018/01/11
Hepatitis c Virus
Ns3 Helicase
Ns5b Rna-dependent Rna Polymerase
High Throughput
Inhibitor
Computational study on the binding and unbinding mechanism of HCV NS5B with the inhibitor GS-461203 and substrate using conventional and steered molecular dynamics simulations
期刊论文
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2016, 卷号: 156, 页码: 72-80
作者:
Pan, DB
;
Niu, YZ
;
Ning, LL
;
Zhang, Y
;
Liu, HX
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/01/12
Hepatitis C Virus NS5B RNA-dependent RNA polymerase
GS-461203
Molecular dynamics simulation
Binding free energy calculations
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
Computational study on the drug resistance mechanism of hepatitis C virus NS5B RNA-dependent RNA polymerase mutants to BMS-791325 by molecular dynamics simulation and binding free energy calculations
会议论文
15th Conference on Chemometrics in Analytical Chemistry, Changsha, PEOPLES R CHINA, JUN 22-26, 2015
作者:
Pan, DB
;
Niu, YZ
;
Xue, WW
;
Bai, QF
;
Liu, HX
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  |  
浏览/下载:3/0
  |  
提交时间:2017/01/20
Drug resistance mechanism
Hepatitis C Virus NS5B RNA-dependent
RNA polymerase
BMS-791325
Molecular dynamics simulation
Binding free energy calculations
Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
期刊论文
CURRENT DRUG TARGETS, 2016, 卷号: 17, 期号: 13, 页码: 1560-1576
作者:
Xie, Yuanchao
;
Ogah, Comfort Alicha
;
Jiang, Xiangrui
;
Li, Jianfeng
;
Shen, Jingshan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Hepatitis C virus
inhibitor
nucleoside
NS5B polymerase
prodrug
SAR
Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors
期刊论文
European Journal of Medicinal Chemistry: Chimie Therapeutique, 2015, 页码: 188-214
作者:
Zhao, Can
;
Wang, Yinhu
;
Ma, Shutao
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
Hepatitis C
NS5B polymerase
Inhibitors
Antiviral therapy
Synthesis
Biological activity
Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 102, 页码: 188-214
作者:
Zhao, Can
;
Wang, Yinhu
;
Ma, Shutao
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
Hepatitis C
NS5B polymerase
Inhibitors
Antiviral therapy
Synthesis
Biological activity
Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 52, 页码: 33-43
作者:
Liu, Ming-Ming
;
Zhou, Lu
;
He, Pei-Lan
;
Zhang, Yi-Nan
;
Zhou, Jia-Yi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Anti-HCV agents
NS5B polymerase
Flavonoids
Ligand-based pharmacophore
Virtual screening
Insight into the Structural Requirements of Benzothiadiazine Scaffold-Based Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors Using 3D-QSAR, Molecular Docking and Molecular Dynamics
期刊论文
current medicinal chemistry, 2011, 卷号: 18, 期号: 26, 页码: 4019-4028
作者:
Zhang, H-X.
;
Li, Y.
;
Wang, X.
;
Xiao, Z-T.
;
Wang, Y-H.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/11/12
HCV NS5B
benzothiadiazine scaffold-based inhibitors
3D-QSAR
CoMFA
CoMSIA
molecular docking
molecular dynamics
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