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CORC

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The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:  Ye, Xiaoqing;  Chen, Gang;  Jin, Jia;  Zhang, Binzhong;  Wang, Yinda
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/24
Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:  Ye, Fei;  Huang, Jing;  Wang, Hongbo;  Luo, Cheng;  Zhao, Kehao
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors 期刊论文
CELL, 2018, 卷号: 175, 期号: 1, 页码: 186-+
作者:  Huang, Xun;  Yan, Juan;  Zhang, Min;  Wang, Yafang;  Chen, Yi
收藏  |  浏览/下载：77/0  |  提交时间：2019/01/08
Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
作者:  Feng, Yuxin;  Xiao, Senhao;  Chen, Yantao;  Jiang, Hao;  Liu, Na
收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis 期刊论文
CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160
作者:  Zhang, Xiong;  Zheng, Xingling;  Yang, Hong;  Yan, Juan;  Fu, Xuhong
收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08
Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 44, 页码: 9352-9361
作者:  Jiang, Hao;  Xing, Jing;  Wang, Chen;  Zhang, Hao;  Yue, Liyan
收藏  |  浏览/下载：108/0  |  提交时间：2019/01/08
Structural basis for activity regulation of MLL family methyltransferases 期刊论文
NATURE, 2016, 卷号: 530, 期号: 7591, 页码: 447-+
作者:  Chen, Yong;  Li, Yanjing;  Han, Jianming;  Zhang, Yuebin;  Cao, Fang
收藏  |  浏览/下载：38/0  |  提交时间：2019/06/20
Structural basis for activity regulation of MLL family methyltransferases 期刊论文
NATURE, 2016, 卷号: 530, 期号: 7591, 页码: 447-+
作者:  Li, Yanjing;  Han, Jianming;  Zhang, Yuebin;  Cao, Fang;  Liu, Zhijun
收藏  |  浏览/下载：28/0  |  提交时间：2017/10/30
Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:  Zhou, Cefan;  Zhang, Yi;  Dai, Jun;  Zhou, Mengzhou;  Liu, Miao
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/05
Loss of polarity protein af6 promotes pancreatic cancer metastasis by inducing snail expression 期刊论文
Nature communications, 2015, 卷号: 6, 页码: 12
作者:  Xu, Yi;  Chang, Renxu;  Peng, Zhiyong;  Wang, Yanmei;  Ji, Weiwei
收藏  |  浏览/下载：44/0  |  提交时间：2019/05/10

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