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复旦大学上海医学院 [9]
武汉物理与数学研究所 [6]
重庆大学 [4]
上海大学 [4]
武汉大学 [4]
兰州大学 [3]
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期刊论文 [48]
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/01
Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis
期刊论文
Chinese Medicine, 2020, 卷号: 15, 期号: 1, 页码: 1-12.
作者:
Xi Liu
;
Qiong Li
;
Xiaolei Cheng
;
Zhichun Liu
;
Xiaoliang Zhao
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/03/10
Oligomannuronate
Type 2 diabetes
Islet amyloid polypeptide
JNK activation
Mitochondrial dysfunction
RINm5F cells
All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 卷号: 87, 期号: 7, 页码: 541-550
作者:
Su, Xinyue
;
Wang, Ke
;
Liu, Na
;
Chen, Jiawen
;
Li, Yong
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/10/14
aggregation
chemical shift restraint
islet amylod polypeptide
metadynamics
Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide
期刊论文
Scientific reports, 2018, 卷号: 8, 页码: 12
作者:
Fang, Xiaocui
;
Yousaf, Maryam
;
Huang, Qunxing
;
Yang, Yanlian
;
Wang, Chen
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  |  
浏览/下载:32/0
  |  
提交时间:2019/04/23
The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 11
作者:
Mo, Yuxiang
;
Brahmachari, Sayanti
;
Lei, Jiangtao
;
Gilead, Sharon
;
Tang, Yiming
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
protein aggregation
human islet amyloid polypeptide
hydroxylated carbon nanotubes
inhibitory mechanism
replica exchange molecular dynamics simulations
TEM experiment
Replica Exchange Molecular Dynamics: A Practical Application Protocol with Solutions to Common Problems and a Peptide Aggregation and Self-Assembly Example.
期刊论文
Methods in molecular biology (Clifton, N.J.), 2018, 卷号: 1777
作者:
Qi Ruxi
;
Wei Guanghong
;
Ma Buyong
;
Nussinov Ruth
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
Free energy landscape
GROMACS
Human islet amyloid polypeptide
Molecular dynamics simulations
Protein aggregation
REMD
Replica exchange method
Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2018, 卷号: 1860, 期号: 9
作者:
Dong, Xuewei
;
Qiao, Qin
;
Qian, Zhenyu
;
Wei, Guanghong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Human islet amyloid polypeptide
Type 2 diabetes
Amyloid aggregates
Conformational ensemble
Membrane disruption
Molecular dynamics simulations
Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
期刊论文
Biochimica et biophysica acta. Biomembranes, 2018
作者:
Dong Xuewei[1]
;
Qiao Qin[2]
;
Qian Zhenyu[3]
;
Wei Guanghong[4]
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/04/24
Amyloid aggregates
Conformational ensemble
Human islet amyloid polypeptide
Membrane disruption
Molecular dynamics simulations
Type 2 diabetes
Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 54, 页码: 145-152
作者:
Zhang, Yue
;
Yu, Xiao-lin
;
Zhu, Jie
;
Liu, Shu-ying
;
Liu, Xiang-meng
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2018/06/11
Type 2 Diabetes Mellitus
Intravenous Immunoglobulin
Islet Amyloid Polypeptide
Islet Inflammation
Toxic Oligomer
Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Liu, Na
;
Yang, Minghui
;
Duan, Mojie
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  |  
浏览/下载:26/0
  |  
提交时间:2017/12/06
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