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Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2022/03/21
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 378, 期号: 1, 页码: 20-30
作者:
Wang, Yu
;
He, Yang
;
Yang, Feipu
;
Abame, Melkamu Alemu
;
Wu, Chunhui
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Efficacy of Pyrotinib in HER2-Overexpressing Salivary Duct Carcinoma With Lung Metastasis: A Case Report
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yang, Zi-yan
;
Huang, Jia-huan
;
Chen, Bo
;
Xu, Chun-wei
;
Lei, Lei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/30
salivary duct carcinoma
tyrosine kinase inhibitor
pyrotinib
HER2 positive
targeted
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:260/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
A comparison of endocrine disruption potential of nonylphenol ethoxylate, vanillin ethoxylate, 4-n-nonylphenol and vanillin in vitro
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 175, 页码: 208-214
作者:
Ji, Xiaoya
;
Li, Na
;
Yuan, Shengwu
;
Zhou, Xiaohong
;
Ding, Fengmei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/10/23
Nonylphenol ethoxylate
Vanillin ethoxylate
4-n-nonylphenol
Vanillin
Nuclear receptors
Two-hybrid yeast
Identification of serotonin 2a receptor as a novel hcv entry factor by a chemical biology strategy
期刊论文
Protein & cell, 2019, 卷号: 10, 期号: 3, 页码: 178-195
作者:
Cao, Lin
;
Chen, Jizheng
;
Wang, Yaxin
;
Yang, Yuting
;
Qing, Jie
收藏
  |  
浏览/下载:484/0
  |  
提交时间:2019/05/08
Hcv
Serotonin 2a receptor
Entry
Antiviral drug
Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2019, 卷号: 59, 期号: 2, 页码: 842-857
作者:
Hou, Tingjun
;
Li, Youyong
;
Yu, Huidong
;
Li, Dan
;
Liu, Hui
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2019/06/24
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:
Hu, Li-Peng
;
Zhang, Xiao-Xin
;
Jiang, Shu-Heng
;
Tao, Ling-Ye
;
Li, Qing
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/12/02
adenosine triphosphate
ar c118925xx
gemcitabine
glucose transporter 1
hypoxia inducible factor 1alpha
Myc protein
platelet derived growth factor beta receptor
platelet derived growth factor receptor
protein kinase Yes
purinergic P2Y receptor antagonist
purinergic P2Y2 receptor
unclassified drug
Yes1 protein, Akt signaling
animal experiment
animal model
animal tissue
Article
cancer inhibition
cancer prognosis
cancer staging
controlled study
drug potentiation
glycolysis
human
human cell
human tissue
inflammation
lymph node metastasis
male
mouse
mouse model
nonhuman
overall survival
pancreas adenocarcinoma
pancreatic ductal carcinoma cell line
Pi3K/Akt signaling
priority journal
RNA sequence
tumor classification
tumor differentiation
tumor microenvironment
tumor volume
tumor xenograft
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Wang, Anhui
;
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/06/20
beta(2)-Adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
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