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科研机构
上海药物研究所 [411]
内容类型
期刊论文 [410]
学位论文 [1]
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2021 [36]
2020 [31]
2019 [32]
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Pharmacolo... [3]
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Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 79-90
作者:
Li, Jin-Feng
;
Zeng, Yan-Bo
;
Li, Wang-Sheng
;
Luo, Hui
;
Zhang, Hai-Yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
Sarcophyton glaucum
Cembranoids
Configuration determination
X-ray diffraction
NMR spectroscopy
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Beshanzoides A-D, unprecedented cycloheptanone-containing polyketides from Penicillium commune P-4-1, an endophytic fungus of the endangered conifer Abies beshanzuensis
期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 63, 页码: 39781-39789
作者:
Chen, Hao-Wei
;
Jiang, Chun-Xiao
;
Li, Jiyang
;
Li, Na
;
Zang, Yi
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/01/18
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 8
作者:
Song, Zilan
;
Liu, Yuting
;
Xie, Chenghu
;
Tong, Xiankun
;
Wang, Xue
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2021/11/04
Choroquine
Aminochloroquine
Antivirus
Anti-inflammatory
Cytokines
Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella
期刊论文
RSC MEDICINAL CHEMISTRY, 2021, 页码: 12
作者:
Guan, Xiang-Na
;
Zhang, Tao
;
Yang, Teng
;
Dong, Ze
;
Yang, Song
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/12/16
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12
作者:
Wang, Lan
;
Zhao, Danfeng
;
Wang, Huan
;
Wang, Lele
;
Liu, Xiaohui
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/12/01
Inflammation
Microglia
LPS
RNA-seq
JAK
STAT signaling pathway
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