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上海药物研究所 [50]
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复旦大学上海医学院 [21]
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The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 页码: 20883-20896
作者:
Wei, Zhenlong
;
Ma, Huiping
;
Xian, Cory J.
;
Wang, Jufang
;
Chen, Keming
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2018/05/31
A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases
期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8
作者:
Li, Conggang
;
Liu, Maili
;
Zhou, Pei
;
Jiang, Ling
;
Liu, Yixiang
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  |  
浏览/下载:40/0
  |  
提交时间:2018/11/05
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:
Xie, Chengying
;
Chen, Xiangling
;
Zheng, Mingyue
;
Liu, Xiaohong
;
Wang, Hongbin
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
BEZ235
drug resistance
mTOR
PI3K
SHR8443
Dual-Functionalized Magnetic Metal-Organic Framework for Highly Specific Enrichment of Phosphopeptides
期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2017, 卷号: 5, 期号: 12, 页码: 11413-11421
作者:
Zhou, Jianqiao
;
Liang, Yulu
;
He, Xiwen
;
Chen, Langxing
;
Zhang, Yukui
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  |  
浏览/下载:34/0
  |  
提交时间:2019/06/20
Phosphopeptide
Enrichment
Magnetic Nanomaterials
Metal-organic Framework
Immobilized Metal Ion Affinity Chromatography
Metal Oxide Affinity Chromatography
Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents
期刊论文
PHARMAZIE, 2017, 卷号: 72, 期号: 12, 页码: 707-713
作者:
Hu, Yuanyuan
;
Ruan, Wenchen
;
Gao, Anhui
;
Zhou, Yubo
;
Gao, Lixin
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1673-1682
作者:
Liu, Shi-en
;
Hu, Jun-chi
;
Zhang, Hao
;
Xu, Pan
;
Wan, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
phosphoglycerate mutase 1 (PGAM1)
human cancers
metabolic target
C-terminal region
conformational changes
molecular dynamics simulation
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270
作者:
Zhang, Wei-yao
;
Lu, Wen-chao
;
Jiang, Hao
;
Lv, Zheng-bing
;
Xie, Yi-qian
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
epigenetics
molecular docking
PRMT1
scaffold hopping
small-molecule inhibitor
Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 61, 页码: 104057-104071
作者:
Kuang, Shan
;
Liu, Ge
;
Cao, Ruobing
;
Zhang, Linlin
;
Yu, Qiang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2018/09/06
Mansouramycin c
Marine-derived Isoquinolinequinone
Reactive Oxygen Species
Mitochondrial Permeability Transition Pore
Anticancer Drug
Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 61, 页码: 104057-104071
作者:
Kuang, Shan
;
Liu, Ge
;
Cao, Ruobing
;
Zhang, Linlin
;
Yu, Qiang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2018/04/02
Mansouramycin c
Marine-derived Isoquinolinequinone
Reactive Oxygen Species
Mitochondrial Permeability Transition Pore
Anticancer Drug
Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 61, 页码: 104057-104071
作者:
Kuang, Shan
;
Liu, Ge
;
Cao, Ruobing
;
Zhang, Linlin
;
Yu, Qiang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
mansouramycin C
marine-derived isoquinolinequinone
reactive oxygen species
mitochondrial permeability transition pore
anticancer drug
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