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Cancer-cell-secreted CXCL11 promoted CD8 T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC 期刊论文
Journal for ImmunoTherapy of Cancer, 2019, 卷号: Vol.7 No.1
作者:  Qun Gao;  Shumin Wang;  Xinfeng Chen;  Shaoyan Cheng;  Zhen Zhang
收藏  |  浏览/下载:11/0  |  提交时间:2019/12/17
Docetaxel  CXCL11  CD8+  T  cells  HER2-CAR  T  cells  high-mobility  group  box-1  Non-small  cell  lung  cancer  
Cancer-cell-secreted CXCL11 promoted CD8 T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC. 期刊论文
Journal for immunotherapy of cancer, 2019, 卷号: No.1, 页码: 42
作者:  Qun Gao;  Shumin Wang;  Xinfeng Chen;  Shaoyan Cheng;  Zhen Zhang
收藏  |  浏览/下载:12/0  |  提交时间:2019/12/17
CD8+  T  cells  CXCL11  Docetaxel  HER2-CAR  T  cells  high-mobility  group  box-1  Non-small  cell  lung  cancer  
Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice 期刊论文
Journal of Functional Foods, 2018, 卷号: 44, 页码: 155-165
作者:  Li, Xiaopeng;  Wu, Qian;  Sui, Yong;  Li, Shuyi;  Xie, Bijun
收藏  |  浏览/下载:48/0  |  提交时间:2019/12/27
A-type procyanidins  Oxidative stress  Glucose homeostasis  Type 2 diabetes  mTOR  ACC1  acetyl coenzyme A carboxylase 1  ACL  ATP-citrate lyase  ALT  alanine aminotransferase  AST  aspartate aminotransferase  AUC  area under curve  BAT  brown adipose tissue  FAS  fatty acid synthase  FFA  free fatty acid  FoxO3a  Forkhead box O3a  FoxO1a  Forkhead box O3a  PKCβ  protein kinase C β  mTOR  mechanistic target of rapamycin  HDL  high-density lipoprotein  GHbA1c  glycated hemoglobin A1c  GK  glucokinase  G-6-Pase  glucose-6-phosphatase  GLP-1  glucagon-like peptide-1  GSH-PX  total glutathione peroxidase  HOMA-IR  homeostatic model assessment of insulin resistance  LDHA  lactate dehydrogenase  LDL  low-density lipoprotein  LPOPC  oligomeric procyanidins of litchi pericarp  MDA  malondialdehyde  MnSOD  manganese superoxide dismutase  mTOR  mechanistic target of rapamycin  OGTT  oral glucose tolerance test  PDH  pyruvate dehydrogenase  PEPCK  phosphoenolpyruvate carboxykinase  PFK  phosphofructokinase  PK  pyruvate kinase  PKCβ  protein kinase C β  PPG  postprandial blood glucose  S6K1  S6 Kinase 1  PKCβ  protein kinase C β  RTK  receptor tyrosine kinase  SREBP-1c  sterol regulatory element-binding protein 1c  ACL  ATP-citrate lyase  ACC1  acetyl coenzyme A carboxylase 1  FAS  fatty acid synthase  SCD1  stearoyl CoA desaturase 1  STZ  streptozotocin  S6K1  S6 kinase 1  PPG  postprandial blood glucose  ROS  reactive oxygen species  TC  total cholesterol  TG  triacylglycerol  STZ  streptozotocin  T-AOC  total antioxidant capacity  T-SOD  total superoxide dismutase  UCP-1  uncoupling protein 1  WAT  white adipose tissue  XOS  xylo-oligosaccharides  
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells 期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:  Yang, Xin;  Xu, Zhipeng;  Zhang, Chunlan;  Cai, Zixin;  Zhang, Jingjing*
收藏  |  浏览/下载:37/0  |  提交时间:2019/12/03
A1c  glycated hemoglobin  AACE  American Association of Clinical Endocrinologists  ACC  acetyl-CoA carboxylase  ADA  American Diabetes Association  Akt/PKB  tyrosine kinase/protein kinase B  AMP  adenosine monophosphate  AMPK  adenosine monophosphate-activated protein  Ang II  angiotensin II  ATP  adenosine triphosphate  BAT  brown adipose tissue  CHOP  CEBP-homologous protein  CEBP  CCAAT enhancer binding protein  CoA  coenzyme A  DPP  Diabetes Prevention Program  EASD  European Association for the Study of Diabetes  eNOS  endothelial nitric oxide synthase  ER  endoplasmic reticulum  FDA  Food and Drug Administration  FFA  free fatty acid  FOXO1  forkhead box protein O1  G6P  glucose 6-phosphate  GDM  gestational diabetes mellitus  GIPR  glucose-dependent insulinotropic polypeptide receptor  GLP-1R  glucagon-like peptide-1 receptor  GLUT1  glucose transporter-1  GLUT4  glucose transporter type 4  GLUTs  glucose transporters  G6P  glucose 6-phosphate, glucose transporter-1  GPR40  G protein-coupled receptor 40  HbA1c  hemoglobin A1c  HGP  hepatic glucose production  HSL  hormone sensitive lipase  IL-6  interleukin 6  INS-1  insulinoma cells in rat  IR  insulin resistance  IRS-1  insulin receptor substrate 1  JNK  c-Jun. N-terminal kinase  Kir6.2  inwardly rectifying potassium/kalium channel  LDs  lipid droplets  LDL  low density lipoprotein  LV  left ventricular  MIN6 cells  mouse insulinoma cells  MAPK  mitogen-activated protein kinases  mPTP  mitochondrial permeability transition pore opening  mTOR  mammalian target of rapamycin  NADPH  nicotinamide adenine dinucleotide phosphate  NF-kappaB  nuclear factors-kappa B  NIT-1 cells  insulinoma cells  p70S6K  p70 ribosomal S6 kinase  PA  palmitic acid  NOS  NADPH oxidase  p38 MAPK  p38 mitogen-activated protein kinase  PA  palmitic acid  PCOS  polycystic ovary syndrome  PGC-1α  peroxisome proliferator-activated receptor-g coactivator-1α  PI3K  phosphatidylinositol 3-kinase  PKB  protein kinase B  PKC  protein kinase C  PPARα  peroxisome-proliferator activated receptor α  PTP  permeability transition pore  RCT  randomized controlled trial  RISK  reperfusion injury salvage kinase  ROS  reactive oxygen species  SERCA2  reticulum sarcoplasmic Ca2 +-ATPase  RISK  reperfusion injury salvage kinase  Smad3  mothers against decapentaplegic homolog 3  SRC-2  steroid receptor coactivator 2  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TGFβ1  transforming growth factor β1  TLR4  Toll-like receptor  TNF-α  tumor necrosis factor α  TR4  testicular receptor 4  UKPDS  United Kingdom Prospective Diabetes Study  VLDL  very low density lipoprotein  Metformin  Pancreatic β Cells  Heart failure  Insulin sensitizer  
The role of miRNA-223 in cancer: Function, diagnosis and therapy 期刊论文
Gene, 2017, 卷号: 616, 页码: 1-7
作者:  Gao, Yunliang;  Lin, Le;  Li, Tao;  Yang, Jinrui*;  Wei, Yongbao*
收藏  |  浏览/下载:27/0  |  提交时间:2019/12/03
miRNAs  MicroRNAs  UTR  The 3′ untranslated region  oncomiRs  Oncogenic miRNAs  miR-223  miRNA-223  T-ALL  T-cell acute lymphoblastic leukemia  AML  Acute myeloid leukemia  NSCLC  Nonsmall cell lung cancer  C/EBP  CCAAT-enhancer-binding protein  NFI-A  Nuclear factor I-A  HSP90B1  Heat Shock Protein 90 kDa Beta Family Member 1  IGF-1R  Insulin-like growth factor-1 receptor  FOXO1  Transcription factor Forkhead box O1  NPC  Nasopharyngeal carcinoma  EMT  Epithelial-to-mesenchymal transformation  Mef2c  Myocyte enhancer factor 2c  EBV  Epstein–Barr virus  JMML  Juvenile myelomonocytic leukemia  EPB41L3  Erythrocyte membrane protein band 4.1-like 3  HCC  Hepatocellular carcinoma  miR-223  Cancer  Biological function  Oncogene  Tumor promoter  Biomarker  Oncotherapy  
miR-34a and miR-125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 卷号: 14, 期号: 6, 页码: 5589-5596
作者:  Shen, Yanxin[1];  Xu, Huiling[2];  Pan, Xiaoyuan[3];  Wu, Weijiang[4];  Wang, Hui[5]
收藏  |  浏览/下载:17/0  |  提交时间:2019/12/24
Expression of E2A in mid-secretory endometrium of women suffering from recurrent miscarriage 期刊论文
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2017, 卷号: 37, 期号: 6
作者:  Yin, Zhi-nang;  Ding, Jin-li;  Zhang, Yi;  Li, Sai-jiao;  Zhang, Yan
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/05
Myocardin: A novel player in atherosclerosis 期刊论文
Atherosclerosis, 2017, 卷号: 257, 页码: 266-278
作者:  Xia, Xiao-Dan;  Zhou, Zhen;  Yu, Xiao-Hua;  Zheng, Xi-Long;  Tang, Chao-Ke*
收藏  |  浏览/下载:26/0  |  提交时间:2019/12/27
Myocardin  Atherosclerosis  Inflammation  Lipid metabolism  VSMC  Abca1  MYOCD  Myocardin  AS  atherosclerosis  SRF  serum response factor  VSMC  vascular smooth muscle cell  Mrtf-A/B  Myocardin-related transcription factors A/B  Mamstr  Mef2-activating SAP transcriptional protein  SAP domain  scaffold attachment factors A and B (SAF-A and -B), Acinus, and PIAS  MADS  MCM1, Agamous, Deficiens, SRF-box transcription factor  TAD  transactivation domain  NTD  N-terminal domain  Arp5  actin-related protein 5  Tead  TEA domain transcription factor  Foxo  forkhead transcription factor  Cdc7  cell division cycle 7  Mef2  myocyte-specific enhancer factor  Nfatc3  nuclear factor of activated T cells c3  hnRNPA1  heterogeneous nuclear ribonucleoprotein A1  Tet2  ten-eleven translocation-2  TGF-β  transforming growth factor-β  URR  upstream repressor region  Klf4  Kruppel-like factor4  PRR  platelet-derived growth factor-BB-responsive region  Pkcα  protein kinase C α  MSCs  mesenchymal stem cells  lncRNAs  long non-coding RNAs  MicroRNAs  small non-encoding RNAs  UTR  un-translated region  Abca1  ATP-binding cassette transporter A1  RCT  reverse cholesterol transport  
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells 期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:  Wang, Jing;  Yang, Xin;  Zhang, Jingjing*
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/03
4E-BP1  4E binding protein  AMPK  AMP-activated protein kinase  ATF6  activating transcription factor 6  ATP  adenosine triphosphate  DEPTOR  DEP domain containing mTOR-interacting protein  CI  complexes I  CII  complex II  CIII  complex III  CIV  complex IV  CV  complex V  eIF2α  Eukaryotic Initiation Factor 2α  ER  Endoplasmic Reticulum  ERAD  ER-associated degradation  ERO1α  ER oxidoreductase 1 α  FoxO1  Forkhead box O1  GβL  G Protein β Subunit Like Protein  GRP78  78 kDa glucose-regulated protein precursor  GSIS  glucose-stimulated insulin secretion  IRE1  Inositol-requiring enzyme 1  IRS1  Insulin receptor substrate 1  IRS2  Insulin receptor substrate 2  mLST8  mammalian lethal with sec-13 protein 8  mSin1  the mammalian stress-activated MAP kinase-interaction protein 1  mtDNA  mitochondrial deoxyribonucleic acid  mTOR  mammalian TOR  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  NADPH oxidase  Nicotinamide adenine dinucleotide phosphate-oxidase  NOS  nitric oxide synthase  O2–·  superoxide anion  H2O2  hydrogen peroxide  OH·  hydroxyl radical  3O2  triplet-state molecular oxygen  OXPHOS  oxidative phosphorylation  CAT  catalase  GPx  glutathioneperoxidase  PERK  Protein kinase R-like endoplasmic reticulum kinase  PDI  ER protein disulfide isomerases  PI3K  the phosphoinositide3-kinase  PRAS40  40-kDa proline-rich Akt substrate  PRAS40  the 40-kDa proline-rich Akt substrate  PROTOR  the protein observed with RICTOR  RAPTOR  regulatory-associated protein of mTOR  RICTOR  The rapamycin-insensitive companion of mTOR  REDD1  DNA damage response 1  RNS  reactive nitrogen species  ROS  reactive oxygen species  RNS  reactive nitrogen species  S6K  S6 kinase  SOD  superoxidedismutase  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TOR  the target of rapamycin  TSC2  Tuberous sclerosis 2  UPR  unfolded protein response  Mitochondrial oxidative stress  ER stress  mTOR  Pancreatic β cells  
Steroid receptor RNA activator: Biologic function and role in disease 期刊论文
Clinica Chimica Acta, 2016, 卷号: 459, 页码: 137-146
作者:  Liu, Chan;  Wu, Hong-Tao;  Zhu, Neng;  Shi, Ya-Ning;  Liu, Zheng
收藏  |  浏览/下载:72/0  |  提交时间:2019/12/03
AF-2  activation function-2  AR  androgen receptor  C/EBPα  ccaat-enhancer-binding protein α  CTCF  CCCTC-binding factor  Ddx5  DEAD box protein 5  ERα  estrogen receptor α  GR  glucocorticoid receptor  Hes1  hairy and enhancer of split-1  HP1γ  heterochromatin protein 1γ  JNK  c-Jun N-terminal kinases  lncRNA  long noncoding RNA  MyoD  myogenic differentiation 1  NANOG  homeobox protein NANOG  NR  nuclear receptor(s)  p38 MAPK  mitogen-activated protein kinase  PACT  protein kinase RNA activator  PCOS  polycystic ovary syndrome  PKR  protein kinase RNA-dependent  PPARγ  Peroxisome Proliferator-Activated Receptor gamma  PR  progesterone receptor  PRC2  polycomb repressive complex 2  preTCRα  pre T-cell antigen receptor alpha  Pus1p  pseudouridine synthesis protein  RAR  retinoic acid receptor  RBP-J  recombination signal-binding protein J  RRM  RNA recognition motif  SF-1  steroidogenic factor 1  SHARP  retinoid and thyroid hormone receptors (SMRT)/HDAC1-associated repressor protein  SLIRP  stem-loop loop-interacting RNA RNA-binding protein  SRA  Steroid receptor RNA activator  SRAP  steroid receptor RNA activator protein  SRC-1  steroid receptor coactivator-1  STR  stem-loop structure  TNFα  tumor necrosis factor α  TRBP  transactivation response RNA-binding protein  TrxG  trithorax group  SRA  Long noncoding RNAs  Nuclear receptor  Transcriptional coactivator  


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