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Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 1, 页码: 82-87
作者:
Chen, Yun
;
Ning, Yi
;
Bai, Gang
;
Tong, Linjiang
;
Zhang, Tao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
IRAK4
PROTAC
protein degrader
scaffolding role
diffuse large B-cell lymphoma
Estimating animal population size with very high-resolution satellite imagery
期刊论文
CONSERVATION BIOLOGY, 2020, 页码: 9
作者:
Zhao, Peng
;
Liu, Shuming
;
Zhou, Yi
;
Lynch, Tim
;
Lu, Wenhu
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  |  
浏览/下载:51/0
  |  
提交时间:2021/04/12
population distribution
population size
remote sensing
wildlife management
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice
期刊论文
DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988
作者:
Xu, Xu
;
Wang, Wei
;
Wang, Zhengyu
;
Lv, Jianlu
;
Xu, Xiaoju
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  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Perfect negative differential resistance, spin-filter and spin-rectification transport behaviors in zigzag-edged delta-graphyne nanoribbon-based magnetic devices
期刊论文
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2019, 卷号: 485, 页码: 136-141
作者:
Cao, Liemao
;
Li, Xiaobo*
;
Zuo, Min
;
Jia, Chunxia
;
Liao, Wenhu
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/24
Spin-charge transport
delta-Graphyne junction
Negative differential resistance
Spin-filtering and rectification
Magnetic configuration
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