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科研机构
大连理工大学 [7]
青岛生物能源与过程研... [2]
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期刊论文 [9]
发表日期
2015 [1]
2014 [4]
2013 [4]
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Novel Mcl-1/Bcl-2 Dual Inhibitors Created by the Structure-Based Hybridization of Drug-Divided Building Blocks and a Fragment Deconstructed from a Known Two-Face BH3 Mimetic
期刊论文
ARCHIV DER PHARMAZIE, 2015, 卷号: 348, 页码: 89-99
作者:
Zhang, Zhichao
;
Su, Pengchen
;
Li, Xiangqian
;
Song, Ting
;
Chai, Gaobo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/09
alpha-Helix
Drug-divided building blocks
Fragment-based
Mcl-1
Bcl-2
Two-Face, Two-Turn alpha-Helix Mimetics Based on a Cross-Acridine Scaffold: Analogues of the Bim BH3 Domain
期刊论文
CHEMBIOCHEM, 2014, 卷号: 15, 期号: 9, 页码: 1280-1285
作者:
Li, Xiangqian
;
Wang, Ziqian
;
Feng, Yingang
;
Song, Ting
;
Su, Pengchen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2015/11/02
acridines
helical structures
Mcl-1
peptidomimetics
two-face
Two-Face, Two-Turn alpha-Helix Mimetics Based on a Cross-Acridine Scaffold: Analogues of the Bim BH3 Domain
期刊论文
CHEMBIOCHEM, 2014, 卷号: 15, 页码: 1280-1285
作者:
Li, Xiangqian
;
Wang, Ziqian
;
Feng, Yingang
;
Song, Ting
;
Su, Pengchen
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/09
acridines
helical structures
Mcl-1
peptidomimetics
two-face
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x(L) and Mcl-1 (vol 21, pg 11, 2013)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 页码: 663-664
作者:
Song, Ting
;
Li, Xiangqian
;
Yang, Ying
;
Wu, Guiye
;
Xie, Shenghui
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/09
Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 页码: 5738-5746
作者:
Li, Xiangqian
;
Liang, Xiaomeng
;
Song, Ting
;
Su, Pengchen
;
Zhang, Zhichao
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/09
Dual inhibitors
Hydrogen bond
Apoptosis
Mcl-1
Bcl-2
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x(L) and Mcl-1
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 1, 页码: 11-20
作者:
Song, Ting
;
Li, Xiangqian
;
Chang, Xilong
;
Liang, Xiaomeng
;
Zhao, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2015/11/02
Pan-Bcl-2 inhibitor
Bcl-2
Mcl-1
p4 Pocket
Apoptosis
Study of binding thermodynamics in the optimization of BH3 mimetics. 2013, 82, 4, 394–400
期刊论文
Chem. Biol. Drug Des., 2013, 卷号: 82, 页码: 394-400
作者:
Zhang ZC(张志超)
;
Zhao Y(赵燕)
;
Song T(宋婷)
;
Liu, Yubo
;
Li, Xiangqian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/13
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-x(L) and Mcl-1
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 页码: 11-20
作者:
Song, Ting
;
Li, Xiangqian
;
Chang, Xilong
;
Liang, Xiaomeng
;
Zhao, Yan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Pan-Bcl-2 inhibitor
Bcl-2
Mcl-1
p4 Pocket
Apoptosis
Study of Binding Thermodynamics in the Optimization of BH3 Mimetics
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 卷号: 82, 页码: 394-400
作者:
Zhang, Zhichao
;
Zhao, Yan
;
Song, Ting
;
Liu, Yubo
;
Li, Xiangqian
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
enthalpy
entropy
Gibbs free energy
hydrogen bond
isothermal titration calorimetry
thermodynamics
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