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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
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  |  
浏览/下载:113/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
期刊论文
AUTOPHAGY, 2021, 卷号: 17
作者:
Klionsky, Daniel J.
;
Abdel-Aziz, Amal Kamal
;
Abdelfatah, Sara
;
Abdellatif, Mahmoud
;
Abdoli, Asghar
收藏
  |  
浏览/下载:267/0
  |  
提交时间:2021/05/31
Autophagosome
cancer
flux
LC3
lysosome
macroautophagy
neurodegeneration
phagophore
stress
vacuole
A phase II randomized trial of sodium oligomannate in Alzheimer's dementia
期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2020, 卷号: 12, 期号: 1, 页码: 10
作者:
Wang, Tao
;
Kuang, Weihong
;
Chen, Wei
;
Xu, Wenwei
;
Zhang, Liming
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  |  
浏览/下载:63/0
  |  
提交时间:2020/12/21
Sodium oligomannate
Efficacy
Safety
Alzheimer's disease
Clinical trial
A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2020, 卷号: 12, 期号: 1
作者:
Wang,Tao
;
Kuang,Weihong
;
Chen,Wei
;
Xu,Wenwei
;
Zhang,Liming
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2020/12/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: 5, 页码: 2709-2722
作者:
Nguyen, Phuong D. M.
;
Zheng, Jie
;
Gremminger, Thomas J.
;
Qiu, Liming
;
Zhang, Dong
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  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
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  |  
浏览/下载:92/0
  |  
提交时间:2020/07/01
Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10
作者:
Gao, Shane
;
Guo, Xuanxuan
;
Zhao, Simeng
;
Jin, Yinpeng
;
Zhou, Fei
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  |  
浏览/下载:32/0
  |  
提交时间:2019/12/05
Solid Fuel Use and Risks of Respiratory Diseases A Cohort Study of 280,000 Chinese Never-Smokers
期刊论文
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 卷号: 199, 期号: 3
作者:
Chan, Ka Hung
;
Kurmi, Om P.
;
Bennett, Derrick A.
;
Yang, Ling
;
Chen, Yiping
收藏
  |  
浏览/下载:130/0
  |  
提交时间:2019/12/05
solid fuels
chronic obstructive pulmonary disease
acute lower respiratory infection
household air pollution
Activation of transition metal oxides by in-situ electro-regulated structure-reconstruction for ultra-efficient oxygen evolution
期刊论文
NANO ENERGY, 2019, 卷号: 58, 页码: 778-785
作者:
Huang, Huawei
;
Yu, Chang
;
Huang, Hongling
;
Zhao, Changtai
;
Qiu, Bo
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/12/02
Transition metal oxides
Structure reconstruction
Electrochemical leaching
Oxygen vacancies
Oxygen evolution reaction
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