CORC

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CORC

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Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199
作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan
收藏  |  浏览/下载：40/0  |  提交时间：2021/11/04
Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 9
作者:  Wang, Yue;  Guo, Shimeng;  Zhuang, Youwen;  Yun, Ying;  Xu, Peiyu
收藏  |  浏览/下载：42/0  |  提交时间：2021/11/04
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:  Wang, Congcong;  Zhang, Yu-Fang;  Guo, Shimeng;  Zhao, Quan;  Zeng, Yanping
收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52 期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 12, 页码: 3275-3284
作者:  Ma, Mengna;  Guo, Shimeng;  Lin, Xi;  Li, Shanshan;  Wu, Yiran
收藏  |  浏览/下载：16/0  |  提交时间：2021/05/24
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 21, 页码: 12748-12772
作者:  Li, Junyou;  Liu, Mengqi;  Li, Yazhou;  Sun, Dan-dan;  Shu, Zhihao
收藏  |  浏览/下载：22/0  |  提交时间：2021/05/24
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:  Wang, Ying;  Zhu, Yao;  Niu, Junxing;  Deng, Qiangqiang;  Guo, Shimeng
收藏  |  浏览/下载：59/0  |  提交时间：2020/12/21
Structural basis of GPBAR activation and bile acid recognition 期刊论文
NATURE, 2020, 页码: 29
作者:  Yang, Fan;  Mao, Chunyou;  Guo, Lulu;  Lin, Jingyu;  Ming, Qianqian
收藏  |  浏览/下载：44/0  |  提交时间：2020/12/24
Structural basis of ligand recognition and self-activation of orphan GPR52 期刊论文
NATURE, 2020, 页码: 21
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu
收藏  |  浏览/下载：162/0  |  提交时间：2020/07/01
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:  Kong, Deyu;  Guo, Shimeng;  Yang, Yushe;  Guo, Bin;  Xie, Xin
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01
Dynamic simulation test of a model of ecological system security for a coastal tourist city 期刊论文
JOURNAL OF DESTINATION MARKETING & MANAGEMENT, 2019, 卷号: 13, 页码: 73-82
作者:  Lu, Xiaoli;  Yao, Shimeng;  Fu, Guo;  Lv, Xiaofei;  Mao, Yanan
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/02

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