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Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118
作者:  Zhou, Xiaoting;  Gao, Yan;  Wang, Weiwei;  Yang, Xiaolin;  Yang, Xiuna
收藏  |  浏览/下载:53/0  |  提交时间:2021/06/15
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 卷号: 538, 页码: 47-53
作者:  Jiang, Yi;  Yin, Wanchao;  Xu, H. Eric
收藏  |  浏览/下载:32/0  |  提交时间:2021/05/24
Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 5, 页码: 1066-1073
作者:  Ye, Fei;  Zhang, Weiyao;  Ye, Xiaoqing;  Jin, Jia;  Lv, Zhengbing
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study 期刊论文
CHEMICAL SCIENCE, 2017, 卷号: 8, 期号: 4, 页码: 2795-2803
作者:  Ge, Guang-Bo;  Dai, Zi-Ru;  Feng, Lei;  Jin, Qiang;  Cheng, Hailing
收藏  |  浏览/下载:19/0  |  提交时间:2019/06/20
Thrombin-linked aptamer assay for detection of platelet derived growth factor BB on magnetic beads in a sandwich format 期刊论文
TALANTA, 2016, 卷号: 158, 期号: 0, 页码: 159-164
作者:  Guo, Limin;  Zhao, Qiang
收藏  |  浏览/下载:15/0  |  提交时间:2017/03/27
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells 期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:  Wang, Jing;  Yang, Xin;  Zhang, Jingjing*
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/03
4E-BP1  4E binding protein  AMPK  AMP-activated protein kinase  ATF6  activating transcription factor 6  ATP  adenosine triphosphate  DEPTOR  DEP domain containing mTOR-interacting protein  CI  complexes I  CII  complex II  CIII  complex III  CIV  complex IV  CV  complex V  eIF2α  Eukaryotic Initiation Factor 2α  ER  Endoplasmic Reticulum  ERAD  ER-associated degradation  ERO1α  ER oxidoreductase 1 α  FoxO1  Forkhead box O1  GβL  G Protein β Subunit Like Protein  GRP78  78 kDa glucose-regulated protein precursor  GSIS  glucose-stimulated insulin secretion  IRE1  Inositol-requiring enzyme 1  IRS1  Insulin receptor substrate 1  IRS2  Insulin receptor substrate 2  mLST8  mammalian lethal with sec-13 protein 8  mSin1  the mammalian stress-activated MAP kinase-interaction protein 1  mtDNA  mitochondrial deoxyribonucleic acid  mTOR  mammalian TOR  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  NADPH oxidase  Nicotinamide adenine dinucleotide phosphate-oxidase  NOS  nitric oxide synthase  O2–·  superoxide anion  H2O2  hydrogen peroxide  OH·  hydroxyl radical  3O2  triplet-state molecular oxygen  OXPHOS  oxidative phosphorylation  CAT  catalase  GPx  glutathioneperoxidase  PERK  Protein kinase R-like endoplasmic reticulum kinase  PDI  ER protein disulfide isomerases  PI3K  the phosphoinositide3-kinase  PRAS40  40-kDa proline-rich Akt substrate  PRAS40  the 40-kDa proline-rich Akt substrate  PROTOR  the protein observed with RICTOR  RAPTOR  regulatory-associated protein of mTOR  RICTOR  The rapamycin-insensitive companion of mTOR  REDD1  DNA damage response 1  RNS  reactive nitrogen species  ROS  reactive oxygen species  RNS  reactive nitrogen species  S6K  S6 kinase  SOD  superoxidedismutase  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TOR  the target of rapamycin  TSC2  Tuberous sclerosis 2  UPR  unfolded protein response  Mitochondrial oxidative stress  ER stress  mTOR  Pancreatic β cells  
Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation 期刊论文
NUCLEIC ACIDS RESEARCH, 2015
Wang, Peng; Yang, Lijiang; Gao, Yi Qin; Zhao, Xin Sheng
收藏  |  浏览/下载:6/0  |  提交时间:2017/12/03
E3泛素连接酶HECTD3修饰MALT1在小鼠T细胞免疫系统中的功能初探 学位论文
硕士, 北京: 中国科学院研究生院, 2014
作者:  陈曦
收藏  |  浏览/下载:111/0  |  提交时间:2016/06/21
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation 期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 卷号: 21, 期号: 9, 页码: 771-777
作者:  Huo, YW;  Nam, KH;  Ding, F;  Lee, HJ;  Wu, LJ
收藏  |  浏览/下载:27/0  |  提交时间:2015/07/22
Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8
作者:  Zhang, Ruihan;  Li, Xin;  Liang, Zhongjie;  Zhu, Kongkai;  Lu, Junyan
收藏  |  浏览/下载:24/0  |  提交时间:2019/01/08


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