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上海药物研究所 [5]
北京大学 [3]
中国科学院大学 [3]
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期刊论文 [25]
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Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118
作者:
Zhou, Xiaoting
;
Gao, Yan
;
Wang, Weiwei
;
Yang, Xiaolin
;
Yang, Xiuna
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/06/15
succinate dehydrogenase
Mycobacterium smegmatis
electron transport chain
cryoelectron microscopy
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 卷号: 538, 页码: 47-53
作者:
Jiang, Yi
;
Yin, Wanchao
;
Xu, H. Eric
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/05/24
COVID-19
SARS-CoV-2
RNA-dependent RNA polymerase
Structure
RNA recognition
Remdesivir
Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 5, 页码: 1066-1073
作者:
Ye, Fei
;
Zhang, Weiyao
;
Ye, Xiaoqing
;
Jin, Jia
;
Lv, Zhengbing
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study
期刊论文
CHEMICAL SCIENCE, 2017, 卷号: 8, 期号: 4, 页码: 2795-2803
作者:
Ge, Guang-Bo
;
Dai, Zi-Ru
;
Feng, Lei
;
Jin, Qiang
;
Cheng, Hailing
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  |  
浏览/下载:19/0
  |  
提交时间:2019/06/20
Thrombin-linked aptamer assay for detection of platelet derived growth factor BB on magnetic beads in a sandwich format
期刊论文
TALANTA, 2016, 卷号: 158, 期号: 0, 页码: 159-164
作者:
Guo, Limin
;
Zhao, Qiang
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  |  
浏览/下载:15/0
  |  
提交时间:2017/03/27
Aptamer
Thrombin
Enzyme label
Protein detection
Affinity binding
Platelet derived growth factor BB
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
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  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation
期刊论文
NUCLEIC ACIDS RESEARCH, 2015
Wang, Peng
;
Yang, Lijiang
;
Gao, Yi Qin
;
Zhao, Xin Sheng
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
RIBOSOMAL-RNA
CRYSTAL-STRUCTURE
SYNTHASE
MECHANISM
COMPLEX
STABILIZATION
PROTEINS
YEAST
RECONSTITUTION
TRANSLATION
E3泛素连接酶HECTD3修饰MALT1在小鼠T细胞免疫系统中的功能初探
学位论文
硕士, 北京: 中国科学院研究生院, 2014
作者:
陈曦
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2016/06/21
HECTD3
蛋白质泛素化
NF-κB
免疫系统
肿瘤免疫
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation
期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 卷号: 21, 期号: 9, 页码: 771-777
作者:
Huo, YW
;
Nam, KH
;
Ding, F
;
Lee, HJ
;
Wu, LJ
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  |  
浏览/下载:27/0
  |  
提交时间:2015/07/22
Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8
作者:
Zhang, Ruihan
;
Li, Xin
;
Liang, Zhongjie
;
Zhu, Kongkai
;
Lu, Junyan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
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