RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

doi:10.1016/j.bbrc.2020.08.116

	RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19
	Jiang, Yi 1,2; Yin, Wanchao 1; Xu, H. Eric 1,2,3
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2021-01-29
卷号	538 页码:47-53
关键词	COVID-19 SARS-CoV-2 RNA-dependent RNA polymerase Structure RNA recognition Remdesivir
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2020.08.116
通讯作者	Jiang, Yi(yijiang@simm.ac.cn) ; Xu, H. Eric(eric.xu@simm.ac.cn)
英文摘要	Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2) has rapidly become a global pandemic. Although great efforts have been made to develop effective therapeutic interventions, only the nucleotide analog remdesivir was approved for emergency use against COVID-19. Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp. These structures also reveal the mechanism of RdRp inhibition by nucleotide inhibitors and offer a molecular template for the development of RdRp-targeting drugs. This review discusses the recognition mechanism of RNA and nucleotide inhibitor by RdRp, and its implication in drug discovery. (c) 2020 Elsevier Inc. All rights reserved.
资助项目	National Key R&D Programs of China[(501100012166%20:) 2018YFA0507002] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; CAS Strategic Priority Research Program[XDB08020303] ; National Natural Science Foundation of China[31770796] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000621177900007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295806]
专题	中国科学院上海药物研究所
通讯作者	Jiang, Yi; Xu, H. Eric
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Yi,Yin, Wanchao,Xu, H. Eric. RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2021,538:47-53.
APA	Jiang, Yi,Yin, Wanchao,&Xu, H. Eric.(2021).RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,538,47-53.
MLA	Jiang, Yi,et al."RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 538(2021):47-53.