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上海药物研究所 [9]
山东大学 [4]
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武汉大学 [3]
南华大学 [2]
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期刊论文 [30]
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Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
TGF-beta 1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway
期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 19, 页码: 3505-3518
作者:
Zhang, Zhaodong
;
Zhang, Xiuzhi
;
Zhao, Dewei
;
Liu, Baoyi
;
Wang, Benjie
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  |  
浏览/下载:28/0
  |  
提交时间:2019/12/02
transforming growth factor 1
osteoinduction
phosphatidylinositol 3-kinase
protein kinase B
mammalian target of rapamycin
S6 kinase 1
Knockdown of Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells
期刊论文
MEDICAL SCIENCE MONITOR, 2019, 卷号: 25
作者:
Huang, Jinling
;
Gao, Likun
;
Li, Bingshu
;
Liu, Cheng
;
Hong, Shasha
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  |  
浏览/下载:33/0
  |  
提交时间:2019/12/05
Autophagy
Hypoxia-Inducible Factor 1, alpha Subunit
Ovarian Neoplasms
Phosphatidylinositol 3-Kinases
Signal Transduction
TOR Serine-Threonine Kinases
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway
期刊论文
BIOLOGICAL TRACE ELEMENT RESEARCH, 2019, 卷号: 190, 期号: 2, 页码: 327-335
作者:
Zhou, Hongming
;
Jiao, Guangjun
;
Dong, Meng
;
Chi, Hai
;
Wang, Hongliang
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  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
Orthosilicic acid
Phosphatidylinositol-4
5-bisphosphate 3-kinase
(PI3K)
Protein kinase B (PKB
Akt)
Mammalian target of rapamycin
(mTOR)
Osteoporosis
Girinimbine Inhibits the Proliferation of Human Ovarian Cancer Cells In Vitro via the Phosphatidylinositol-3-Kinase (PI3K)/Akt and the Mammalian Target of Rapamycin (mTOR) and Wnt/beta-Catenin Signaling Pathways
期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24
作者:
Xin, Qiu
;
Muer, An
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Apoptosis
Cell Migration Inhibition
Ovarian Neoplasms
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K–Akt–mTOR Pathway
期刊论文
Biological Trace Element Research, 2018
作者:
Zhou H.
;
Jiao G.
;
Dong M.
;
Chi H.
;
Wang H.
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Mammalian target of rapamycin (mTOR)
Orthosilicic acid
Osteoporosis
Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)
Protein kinase B (PKB/Akt)
Mangiferin Potentiates Neuroprotection by Isoflurane in Neonatal Hypoxic Brain Injury by Reducing Oxidative Stress and Activation of Phosphatidylinositol-3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling
期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24, 页码: 7459-7468
作者:
Xi, Jia-shui
;
Wang, Yu-fen
;
Long, Xin-xin
;
Ma, Yan
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Brain Injuries
Cell Hypoxia
Isoflurane
Phosphatidylinositol 3-Kinases
Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 卷号: 42, 期号: 4
作者:
Li, Xuefei
;
Hu, Xiaorong
;
Wang, Jichun
;
Xu, Weipan
;
Yi, Chunfeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
autophagy
hesperidin
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin
myocardial ischemia/reperfusion injury
LY294002
Dual inhibition of mTORC1/2 by DCZ0358 induces cytotoxicity in multiple myeloma and overcomes the protective effect of the bone marrow microenvironment
期刊论文
CANCER LETTERS, 2018, 卷号: 421, 页码: 135-144
作者:
Gao, Lu
;
Li, Bo
;
Yang, Guang
;
Liu, Peng
;
Lan, Xiucai
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
mTOR
Multiple myeloma
Bone marrow microenvironment
Apoptosis
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:
Xie, Chengying
;
Chen, Xiangling
;
Zheng, Mingyue
;
Liu, Xiaohong
;
Wang, Hongbin
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
BEZ235
drug resistance
mTOR
PI3K
SHR8443
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