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上海药物研究所 [33]
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海洋研究所 [9]
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Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia
期刊论文
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2022
作者:
Wu, Kun-Chang
;
Chu, Po-Chen
;
Cheng, Yu-Jung
;
Li, Chia-Ing
;
Tian, Jingkui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/23
Cachexia
Traditional Chinese medicine
Muscle atrophy
C-26 tumour-bearing model
Caenorhabditis elegans model
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:
Jiang, Bo
;
Luo, Jiao
;
Guo, Shuju
;
Wang, Lijun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/05/11
Type 2 diabetes mellitus
Protein tyrosine phosphatase 1B inhibitors
Thiazolidinedione
Insulin signaling
Anti-diabetic activities
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:
Luo, Jiao
;
Zheng, Meiling
;
Jiang, Bo
;
Li, Chao
;
Guo, Shuju
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2020/09/29
bromophenol
PTP1B inhibitor
selectivity
cell permeability
oral bioavailability
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes
期刊论文
MARINE DRUGS, 2020, 卷号: 18, 期号: 5, 页码: 13
作者:
Luo, Jiao
;
Hou, Yufei
;
Xie, Mengyue
;
Ma, Wanli
;
Shi, Dayong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/09/25
CYC31
PTP1B inhibitor
insulin resistance
fatty acid oxidization
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis
期刊论文
JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 卷号: 12, 期号: 4, 页码: 277-290
作者:
Zhao, Mingxia
;
Shen, Lihong
;
Ouyang, Zijun
;
Li, Manru
;
Deng, Guoliang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
hnRNP A1
insulin resistance
hepatic steatosis
glycogen synthesis
TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56
作者:
Huang, Suling
;
Ma, Shanyao
;
Ning, Mengmeng
;
Yang, Wenji
;
Ye, Yangliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
TGR5
Glucose homeostasis
Insulin resistance
Skeletal muscle
Type 2 diabetes
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells
期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 卷号: 308, 页码: 164-169
作者:
Luo, Yali
;
Xie, Heidi Qunhui
;
Chen, Yangsheng
;
Xia, Yingjie
;
Sha, Rui
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/09/10
Dioxin
Acetylcholinesterase
Muscle contraction
Aryl hydrocarbon receptor
Primary skeletal muscle cell
The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 27, 页码: 10415-10427
作者:
Wang, Fang
;
Yang, Xiaoyan
;
Lu, Yanting
;
Li, Zhenghui
;
Xu, Yuhui
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/09/10
glucose metabolism
liver kinase B1 (LKB1)
AMP-activated kinase (AMPK)
glucose transporter type 4 (GLUT4)
fungi
Basidiomycete
diabetes
energy sensing
glucose homeostasis
sesquiterpene
Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
期刊论文
EPIGENETICS & CHROMATIN, 2019, 卷号: 12, 页码: -
作者:
Zhang, Ting
;
Guan, Xiaowen
;
Choi, Un Lam
;
Dong, Qiang
;
Lam, Melody M. T.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/10/21
AMPK
TET2
Phosphorylation
Myogenesis
PAX7
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:
Li, Xiangqian
;
Xu, Qi
;
Li, Chao
;
Luo, Jiao
;
Li, Xiuxue
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/05/15
Anti-diabetic
PTP1B inhibitor
Selectivity
BKS db mice
Toxicity
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