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Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/03/21
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:
Wang, Congcong
;
Zhang, Yu-Fang
;
Guo, Shimeng
;
Zhao, Quan
;
Zeng, Yanping
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Sanguinarine is an agonist of TRPA1 channel
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 卷号: 534, 页码: 226-232
作者:
Chi, Hao
;
Zhang, Xian
;
Chen, Xueqin
;
Fang, Sui
;
Ding, Qiang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
Sanguinarine
Alkaloid
TRPA1
Agonist
Pain
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
;
Wang, Yujun
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  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
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  |  
浏览/下载:92/0
  |  
提交时间:2020/07/01
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:263/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Enantioselective determination of ketamine in dog plasma by chiral liquid chromatography-tandem mass spectrometry
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2019, 卷号: 33, 期号: 9, 页码: 8
作者:
Li, Ranran
;
Zhong, Kan
;
Jiang, Jinfang
;
Zhan, Yuan
;
Chen, Xiaoyan
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
chiral stationary phases
enantioselective LC-MS
MS
ketamine
stereoselective pharmacokinetics
Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans
期刊论文
DRUG METABOLISM AND DISPOSITION, 2019, 卷号: 47, 期号: 8, 页码: 843-853
作者:
Li, Xiuli
;
Sun, Jingchao
;
Guo, Zitao
;
Zhong, Dafang
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
A meta-analysis of naldemedine for the treatment of opioid-induced constipation
期刊论文
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2019, 卷号: 12, 期号: 2
作者:
Song, Xuesong
;
Qu, Xiaoyu
;
Dong, Naifu
;
Teng, Shiyong
;
Wang, Dunwei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Meta-analysis
naldemedine
opioid-induced constipation
chronic severe pain
mu-receptor antagonist
efficacy
safety
Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 21, 页码: 9621-9636
作者:
Peng, Panfeng
;
Chen, Huan
;
Zhu, Ya
;
Wang, Zhilong
;
Li, Jian
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
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