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Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment
via
a "turn-on" fluorescent probe
期刊论文
ANALYST, 2024, 页码: 10
作者:
Wang, Lingxiao
;
Wang, Lingyun
;
Sun, Xiao
;
Fu, Lili
;
Wang, Xinlei
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:
Qu, Bingxue
;
Xu, Yongjin
;
Lu, Yang
;
Zhuang, Weihao
;
Jin, Xinxin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/12/23
XPO1
Multiple myeloma
MM.1S
N-phenylsulfonamide
Oral administration
Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry
期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2022, 卷号: 36
作者:
Zhang, Hongjian
;
Hu, Zhen
;
Zhang, Huiping
;
Sun, Xiyan
;
Yang, Jianming
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/03/28
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
Lan, Xiao-fang
;
Olaleye, Olajide E.
;
Lu, Jun-lan
;
Yang, Wei
;
Du, Fei-fei
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Pyrrolidinyl Synthetic Cathinones alpha-PHP and 4F-alpha-PVP Metabolite Profiling Using Human Hepatocyte Incubations
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 1, 页码: 17
作者:
Carlier, Jeremy
;
Diao, Xingxing
;
Giorgetti, Raffaele
;
Busardo, Francesco P.
;
Huestis, Marilyn A.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/05/24
alpha-PHP
PV7
4F-alpha-PVP
novel psychoactive substance
synthetic cathinone
bath salt
hepatocyte metabolism
liquid chromatography-high resolution tandem mass spectrometry
Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 13
作者:
Wang, Yuhong
;
Mi, Tian
;
Li, Yiming
;
Kan, Weijuan
;
Xu, Gaoya
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Lenalidomide
Multiple myeloma
MM.1S
Late-stage sulfuration
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