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Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2 期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 2, 页码: 823-834
作者:  Xie, Yongsheng;  Li, Bo;  Bu, Wenxuan;  Gao, Lu;  Zhang, Yong
收藏  |  浏览/下载:98/0  |  提交时间:2019/01/08
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:  Qian, Jianchang;  Chen, Yaqing;  Meng, Tao;  Ma, Lanping;  Meng, Lanfang
收藏  |  浏览/下载:34/0  |  提交时间:2019/01/08
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells 期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:  Wang, Jing;  Yang, Xin;  Zhang, Jingjing*
收藏  |  浏览/下载:28/0  |  提交时间:2019/12/03
4E-BP1  4E binding protein  AMPK  AMP-activated protein kinase  ATF6  activating transcription factor 6  ATP  adenosine triphosphate  DEPTOR  DEP domain containing mTOR-interacting protein  CI  complexes I  CII  complex II  CIII  complex III  CIV  complex IV  CV  complex V  eIF2α  Eukaryotic Initiation Factor 2α  ER  Endoplasmic Reticulum  ERAD  ER-associated degradation  ERO1α  ER oxidoreductase 1 α  FoxO1  Forkhead box O1  GβL  G Protein β Subunit Like Protein  GRP78  78 kDa glucose-regulated protein precursor  GSIS  glucose-stimulated insulin secretion  IRE1  Inositol-requiring enzyme 1  IRS1  Insulin receptor substrate 1  IRS2  Insulin receptor substrate 2  mLST8  mammalian lethal with sec-13 protein 8  mSin1  the mammalian stress-activated MAP kinase-interaction protein 1  mtDNA  mitochondrial deoxyribonucleic acid  mTOR  mammalian TOR  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  NADPH oxidase  Nicotinamide adenine dinucleotide phosphate-oxidase  NOS  nitric oxide synthase  O2–·  superoxide anion  H2O2  hydrogen peroxide  OH·  hydroxyl radical  3O2  triplet-state molecular oxygen  OXPHOS  oxidative phosphorylation  CAT  catalase  GPx  glutathioneperoxidase  PERK  Protein kinase R-like endoplasmic reticulum kinase  PDI  ER protein disulfide isomerases  PI3K  the phosphoinositide3-kinase  PRAS40  40-kDa proline-rich Akt substrate  PRAS40  the 40-kDa proline-rich Akt substrate  PROTOR  the protein observed with RICTOR  RAPTOR  regulatory-associated protein of mTOR  RICTOR  The rapamycin-insensitive companion of mTOR  REDD1  DNA damage response 1  RNS  reactive nitrogen species  ROS  reactive oxygen species  RNS  reactive nitrogen species  S6K  S6 kinase  SOD  superoxidedismutase  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TOR  the target of rapamycin  TSC2  Tuberous sclerosis 2  UPR  unfolded protein response  Mitochondrial oxidative stress  ER stress  mTOR  Pancreatic β cells  
Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: Role of mTORC2/SGK1 pathway 期刊论文
Experimental Cell Research, 2015, 卷号: Vol.331 No.1, 页码: 164-175
作者:  Jing He;  Di Qi;  Dao-xin Wang;  Wang Deng;  Yuan Ye
收藏  |  浏览/下载:8/0  |  提交时间:2019/02/25
The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206 期刊论文
2015, 卷号: 14, 期号: 2, 页码: 232-242
作者:  Wang, Hongtao;  Huang, Fang;  Wang, Jian;  Wang, Peng;  Lv, Wenjie
收藏  |  浏览/下载:2/0  |  提交时间:2020/01/13
SIRT1 in cardiovascular aging 期刊论文
Clinica Chimica Acta, 2014, 卷号: 437, 页码: 106-114
作者:  Luo, Xin-Yuan;  Qu, Shun-Lin;  Tang, Zhi-Han;  Zhang, Yuan;  Liu, Mi-Hua
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/27
CVD  cardiovascular disease  SIRT1  sirtuin1  LV  left ventricular  Sir2  silent information regulator 2  rDNA  recombinant DNA  PI3K  phosphoinositide 3-hydroxykinase  NF-κB  nuclear factor kappa B  FOXOs  forkhead box O transcription factors  ROS  reactive oxygen species  mTOR  mammalian (or mechanistic) target of rapamycin  H2O2  hydrogen peroxide  NO  nitric oxide  GADD45  DNA damage-inducible protein 45  MnSOD  manganese superoxide dismutase  H2S  hydrogen sulfide  HUVECs  human umbilical vein endothelial cells  eNOS  endothelial nitric oxide synthase  miR  microRNA  CR  caloric restriction  AP-1  activator protein 1  STACs  small molecule activators of SIRT1  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  LC  light chain  IGF  insulin-like growth factor  Atgs  autophagy-related genes  SIRT1  Cardiovascular aging  Oxidative stress  Inflammation  Autophagy  Anti-aging strategies  
IKK interacts with rictor and regulates mTORC2 期刊论文
CELLULAR SIGNALLING, 2013, 卷号: 25, 期号: 11
作者:  Xu, Yuanfei;  Lai, Eryong;  Liu, Jun;  Lin, Jun;  Yang, Cuilan
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/04
Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway 期刊论文
genes development, 2013
Lee, Kyu-Sun; Wu, Zhihao; Song, Yan; Mitra, Siddhartha S.; Feroze, Abdullah H.; Cheshier, Samuel H.; Lu, Bingwei
收藏  |  浏览/下载:3/0  |  提交时间:2015/11/16
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling 期刊论文
http://dx.doi.org/10.1002/emmm.201201369, 2013
Wang, Rong-Hao; He, Jian-Ping; Su, Mao-Long; Luo, Jie; Xu, Ming; Du, Xiao-Dan; Chen, Hang-Zi; Wang, Wei-Jia; Wang, Yuan; Zhang, Nan; Zhao, Bi-Xing; Zhao, Wen-Xiu; Shan, Zhong-Gui; Han, Jiahuai; Chang,
收藏  |  浏览/下载:3/0  |  提交时间:2013/12/12
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling 期刊论文
http://dx.doi.org/10.1002/emmm.201201369, 2013
Wang, Rong-Hao; He, Jian-Ping; Su, Mao-Long; Luo, Jie; Xu, Ming; Du, Xiao-Dan; Chen, Hang-Zi; Wang, Wei-Jia; Wang, Yuan; Zhang, Nan; Zhao, Bi-Xing; Zhao, Wen-Xiu; Shan, Zhong-Gui; Han, Jiahuai; Chang,Chawnshang; Wu,Qiao
收藏  |  浏览/下载:3/0  |  提交时间:2013/12/12


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