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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Paralichthys olivaceus
MLKL-mediated necroptosis is activated by RIPK1/3 and involved in anti-microbial immunity
期刊论文
FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15, 页码: 11
作者:
Hao, Kangwei
;
Xu, Hang
;
Jiang, Shuai
;
Sun, Li
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  |  
浏览/下载:1/0
  |  
提交时间:2024/04/07
Paralichthys olivaceus
necroptosis
RIPK1
RIPK3
MLKL
immune defense
Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 263, 页码: 19
作者:
Wang, Chaogang
;
Du, Mingyang
;
Jiang, Zhuxiang
;
Cong, Rihao
;
Wang, Wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/13
Heat stress
Oysters
Crassostrea angulata
Crassostrea gigas
Phosphorylation
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
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  |  
浏览/下载:10/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
A dynamic phosphoproteomic analysis provides insight into the C4 plant maize (Zea mays L.) response to natural diurnal changes
期刊论文
PLANT JOURNAL, 2023, 卷号: 113, 期号: 2, 页码: 291-307
作者:
Gao, Zhi-Fang
;
Yang, Xiu
;
Mei, Yingchang
;
Zhang, Jiao
;
Chao, Qing
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  |  
浏览/下载:1/0
  |  
提交时间:2024/03/07
maize
C4
phosphoproteome
kinase-substrate network
light and temperature
Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:
Liang, Xiaofei
;
Wang, Chun
;
Wang, Beilei
;
Liu, Juan
;
Qi, Shuang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/12/23
CSF1R inhibitor
Kinase inhibitor
Macrophage polarization
Potential roles of MEK1 on aging in Argopecten scallops
期刊论文
FRONTIERS IN MARINE SCIENCE, 2022, 卷号: 9, 页码: 16
作者:
Yuan, Ke
;
Lu, Xia
;
Ning, Junhao
;
Chen, Min
;
Wang, Quanchao
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  |  
浏览/下载:9/0
  |  
提交时间:2023/08/17
bivalve
Argopecten scallops
MEK1
aging
nutrition restriction
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
期刊论文
BIOACTIVE MATERIALS, 2022, 卷号: 17, 页码: 406-424
作者:
Wang, Jin
;
Xie, Si-an
;
Li, Ning
;
Zhang, Tao
;
Yao, Weijuan
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2022/06/10
Matrix stiffness
Inflammation
DDR1
DNMT1
Mechanotransduction
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wang, Zuo-wei
;
Zou, Feng-ming
;
Wang, Ao-li
;
Yang, Jing
;
Jin, Rui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/12/22
AZD4547
RIPK1
inhibitors
SIRS model
anti-necroptosis
A positive feedback circuit comprising p21 and HIF-1 alpha aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis
期刊论文
FASEB JOURNAL, 2022, 卷号: 36, 期号: 3
作者:
Jin, Xiaodong
;
Kuang, Yanbei
;
Li, Linying
;
Li, Hongbin
;
Zhao, Ting
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/04/21
glioblastoma
glycolysis
HIF-1 alpha
hypoxia
p21
radioresistance
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