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上海药物研究所 [5]
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Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
The association of plasma peroxiredoxin 3 with insulin in pregnant women
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 508, 期号: 3, 页码: 805-810
作者:
Wang, Li
;
Hao, Jun-Mei
;
Yu, Ai-Qun
;
Li, Tian-Tian
;
Liu, Ran-Ran
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/03/01
Peroxiredoxin
Oxidative Stress
Gestational Diabetes Mellitus
Insulin Resistance
Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells
期刊论文
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2018, 卷号: 137, 期号: 2, 页码: 212-219
作者:
Edirs, S (Edirs, Salamet)[ 1,3 ]
;
Jiang, L (Jiang, Lan)[ 1,2 ]
;
Xin, XL (Xin, XueLei)[ 1,2 ]
;
Aisa, HA (Aisa, Haji Akber)[ 1,2 ]
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2018/09/27
Type 2 Diabetes
Kursi Wufarikun Ziyabit
Anti-diabetic Activity
Insulin Signaling Pathway
Endoplasmic Reticulum Stress
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717
作者:
Li, He
;
Huang, Qi
;
Chen, Cheng
;
Xu, Bin
;
Wang, He-Yao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
红花降糖有效部位的谱效关系及其作用机理研究
学位论文
硕士, 北京: 中国科学院大学, 2016
作者:
武鹤婷
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2016/09/27
糖尿病
胰岛素抵抗
内质网应激
谱效关系
红花
新疆药用植物沙枣活性多肽的提取分离与制备工艺研究
学位论文
硕士, 北京: 中国科学院大学, 2016
作者:
艾合米丁·外力
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2017/08/22
沙枣
多肽提取分离
氨基酸序列
生物活性
提取工艺
Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice
期刊论文
Journal of Autoimmunity, 2016, 卷号: 72, 页码: 47-56
作者:
Hu, Youjia
;
Jin, Ping
;
Peng, Jian
;
Zhang, Xiaojun
;
Wong, F. Susan
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/03
Type 1 diabetes
Gut microbiota
Antibiotic treatment
T1D
type 1 diabetes
HLA
human leukocyte antigen
IDDM1
insulin-dependent diabetes mellitus 1
NOD
non-obese diabetic
TCR
T cell receptor
Neo
neomycin
Van
vancomycin
ICC
intracellular cytokine
PMA
Phorbol 12-myristate 13-acetate
SI
stimulation index
SPL
spleen
MLN
mesenteric lymph nodes
PLN
pancreatic lymph nodes
PP
Peyer's patches
APC
antigen presenting cell
DC
dendritic cell
IGRP
islet-specific glucose-6-phosphatase catalytic subunit-related protein
G+
Gram positive
G−
Gram negative
The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo
期刊论文
BIOCHEMICAL JOURNAL, 2015, 卷号: 466, 页码: 467-473
作者:
Luo, Xiao
;
Li, Ting
;
Zhu, Yue
;
Dai, Yunbin
;
Zhao, Jianwei
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
GLP-1
hypoglycaemic effect
INSL5
insulin
RXFP4
Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2013, 卷号: 150, 期号: 1, 页码: 285-297
作者:
Yao, Xin-gang
;
Chen, Fanglei
;
Li, Ping
;
Quan, Lingling
;
Chen, Jing
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Vindoline
Type 2 diabetes
Glucose-stimulated insulin secretion
beta-cell dysfunction
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