The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo

doi:10.1042/BJ20141113

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo
	Luo, Xiao 1,2; Li, Ting 1,2; Zhu, Yue 1,2; Dai, Yunbin 1,2; Zhao, Jianwei 1,2; Guo, Zhan-Yun 3; Wang, Ming-Wei1,2
刊名	BIOCHEMICAL JOURNAL
	2015-03-15
卷号	466 页码:467-473
关键词	Type 2 diabetes mellitus GLP-1 hypoglycaemic effect INSL5 insulin RXFP4
ISSN号	0264-6021
DOI	10.1042/BJ20141113
文献子类	Article
英文摘要	Insulin-like peptide 5 (INSL5), a member of the insulin/relaxin superfamily, can activate the G-protein-coupled receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), but its precise biological functions are largely unknown. Recent studies suggest that INSL5/RXFP4 is involved in the control of food intake and glucose homoeostasis. We report in the present study that RXFP4 is present in the mouse insulinoma cell line MIN6 and INSL5 augments glucose-stimulated insulin secretion (GSIS) both in vitro and in vivo. RXFP4 is also expressed in the mouse intestinal L-cell line GLUTag and INSL5 is capable of potentiating glucose-dependent glucagon-like peptide-1 (GLP-1) secretion in GLUTag cells. We propose that the insulinotrophic effect of INSL5 is probably mediated through stimulation of insulin/GLP-1 secretion and the INSL5/RXFP4 system may be a potential therapeutic target for Type 2 diabetes.
资助项目	National Health and Family Planning Commission of China[2012ZX09304-011] ; National Health and Family Planning Commission of China[2013ZX09401003-005] ; National Health and Family Planning Commission of China[2013ZX09507-001] ; National Health and Family Planning Commission of China[2013ZX09507-002] ; Shanghai Science and Technology Development Fund[13DZ2290300] ; Thousand Talents Program in China[00000000]
WOS关键词	GLUCOSE-HOMEOSTASIS ; BETA-CELLS ; SECRETION ; RECEPTORS ; INSL5 ; G-PROTEIN-COUPLED-RECEPTOR-119 ; IDENTIFICATION ; DISCOVERY ; AGONIST ; RXFP4
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	PORTLAND PRESS LTD
WOS记录号	WOS:000351687000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276603]
专题	国家新药筛选中心
通讯作者	Wang, Ming-Wei
作者单位	1.Natl Ctr Drug Screening, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 200031, Peoples R China; 3.Tongji Univ, Coll Life Sci & Technol, Inst Prot Res, Shanghai 200092, Peoples R China
推荐引用方式 GB/T 7714	Luo, Xiao,Li, Ting,Zhu, Yue,et al. The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo[J]. BIOCHEMICAL JOURNAL,2015,466:467-473.
APA	Luo, Xiao.,Li, Ting.,Zhu, Yue.,Dai, Yunbin.,Zhao, Jianwei.,...&Wang, Ming-Wei.(2015).The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.BIOCHEMICAL JOURNAL,466,467-473.
MLA	Luo, Xiao,et al."The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo".BIOCHEMICAL JOURNAL 466(2015):467-473.