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期刊论文 [36]
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浏览/检索结果:
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Determination of the antidiabetic chemical basis of Phellodendri Chinensis Cortex by integrating hepatic disposition in vivo and hepatic gluconeogenese inhibition in vitro
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 263, 页码: 10
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Hu, Pei
;
Yu, Yanyan
;
Li, Zhixiong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2020/12/21
Phellodendri Chinensis cortex
Hepatic disposition
Pharmacokinetics
Berberine
Metabolites
Hepatic gluconeogenesis
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
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  |  
浏览/下载:207/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Liver-Target and Glucose-Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 15
作者:
Wang, Aohua
;
Fan, Weiwei
;
Yang, Tiantian
;
He, Shufang
;
Yang, Yiwei
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  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
glucose responsive
insulin secretion
liver target
oral drug delivery
polymersomes
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 43, 页码: 21732-21738
作者:
Liu, Bin
;
Zhang, Zhijian
;
Hu, Yanyun
;
Lu, Yan
;
Li, Duanzhuo
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  |  
浏览/下载:59/0
  |  
提交时间:2020/07/01
type 2 diabetes
gluconeogenesis
hepatic glucose production
ER stress
USP14
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
A preclinical overview of metformin for the treatment of type 2 diabetes
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 106, 页码: 1227-1235
作者:
Zhou, Tingting
;
Xu, Xin
;
Du, Mengfan
;
Zhao, Tong
;
Wang, Jiaying
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Gluconeogenesis
Insulin sensitivity
Mechanism
Metformin
Type 2 diabetes (T2D)
Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice
期刊论文
JOURNAL OF FUNCTIONAL FOODS, 2018, 卷号: 45, 页码: 223-232
作者:
Patterson, Andrew D.
;
Tian, Yuan
;
Nichols, Robert G.
;
Roy, Pratiti
;
Gui, Wei
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2018/08/15
Mushroom
Succinate
Propionate
Microbiota
Intestinal Gluconeogenesis
Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317
作者:
Ma, Fei
;
Liu, Jian
;
Zhou, Tingting
;
Lei, Min
;
Chen, Jing
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/01/08
Thienol2,3-b]pyridine derivatives
Structure-activity relationships (SARs)
Hepatic gluconeogenesis
Type 2 diabetes mellitus (T2DM)
Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment
期刊论文
FRONTIERS IN PHYSIOLOGY, 2018, 卷号: 9
作者:
Li, Min
;
Li, Xiaoying
;
Zhang, Huijie
;
Lu, Yan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
metformin
type 2 diabetes
gluconeogenesis
hepatic glucose production
cancer
cell proliferation
AMPK
mTOR
Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice
期刊论文
FRONTIERS IN PHYSIOLOGY, 2018, 卷号: 9
作者:
Du, Qun
;
Zhang, Shuihong
;
Li, Aiyun
;
Mohammad, Imran S.
;
Liu, Baolin
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
astragaloside IV
Akt
PDE3B
lipolysis
gluconeogenesis
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