×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [16]
西安交通大学 [8]
中国医学科学院 北京... [3]
西双版纳热带植物园 [2]
复旦大学上海医学院 [2]
上海生物化学与细胞生... [2]
更多...
内容类型
期刊论文 [36]
发表日期
2019 [5]
2018 [4]
2017 [2]
2016 [5]
2015 [1]
2014 [2]
更多...
学科主题
Biochemist... [1]
Biochemist... [1]
Chemistry [1]
Pharmacolo... [1]
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共36条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 页码: 1253-1262
作者:
Ma Shuting
;
Zhao Yun
;
Cao Miaomiao
;
Sun Chaofeng
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/11/19
Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene
期刊论文
2019
作者:
Yu Haiyun
;
Meng Yanhai
;
Zhang Shuhong
;
Tian Chen
;
Wu Fang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections
期刊论文
ACS INFECTIOUS DISEASES, 2018, 卷号: 4, 期号: 3, 页码: 208-217
作者:
Li, Baoli
;
Ni, Shuaishuai
;
Chen, Feifei
;
Mao, Fei
;
Wei, Hanwen
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Staphylococcus aureus
diapophytoene desaturase
methicillin-resistant Staphylococcus aureus
hERG safety
F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels
期刊论文
MICROSCOPY RESEARCH AND TECHNIQUE, 2018, 卷号: 81, 页码: 663-668
作者:
Cheng, Gong
;
Wu, Jine
;
Han, Wenqi
;
Sun, Chaofeng
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/11/19
drug-induced LQTS
Dofetilide
whole-cell patch
mutation
hERG gene
An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Jin, Tao
;
Hu, Bingxue
;
Chen, Shanshan
;
Wang, Qiang
;
Dong, Xue
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
FHND004
EGFR inhibitor
human ether-a-go-go-related gene
inhibitory effect
cardiac safety
Machine Learning-Based Modeling of Drug Toxicity
期刊论文
Methods in molecular biology (Clifton, N.J.), 2018, 卷号: 1754, 页码: 247-264
作者:
Lu, Jing
;
Lu, Dong
;
Fu, Zunyun
;
Zheng, Mingyue
;
Luo, Xiaomin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532
作者:
Chen, Wen-hua
;
Song, Shan-shan
;
Qi, Ming-hui
;
Huan, Xia-juan
;
Wang, Ying-qing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
PARP-1 inhibitor
olaparib
breast cancer
BRCA-deficient tumors
©版权所有 ©2017 CSpace - Powered by
CSpace