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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/01
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/01
Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway. 期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 页码: 1253-1262
作者:  Ma Shuting;  Zhao Yun;  Cao Miaomiao;  Sun Chaofeng
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/19
Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene 期刊论文
2019
作者:  Yu Haiyun;  Meng Yanhai;  Zhang Shuhong;  Tian Chen;  Wu Fang
收藏  |  浏览/下载:6/0  |  提交时间:2020/01/03
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang
收藏  |  浏览/下载:52/0  |  提交时间:2020/07/01
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections 期刊论文
ACS INFECTIOUS DISEASES, 2018, 卷号: 4, 期号: 3, 页码: 208-217
作者:  Li, Baoli;  Ni, Shuaishuai;  Chen, Feifei;  Mao, Fei;  Wei, Hanwen
收藏  |  浏览/下载:48/0  |  提交时间:2019/01/08
F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels 期刊论文
MICROSCOPY RESEARCH AND TECHNIQUE, 2018, 卷号: 81, 页码: 663-668
作者:  Cheng, Gong;  Wu, Jine;  Han, Wenqi;  Sun, Chaofeng
收藏  |  浏览/下载:3/0  |  提交时间:2019/11/19
An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:  Jin, Tao;  Hu, Bingxue;  Chen, Shanshan;  Wang, Qiang;  Dong, Xue
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/05
Machine Learning-Based Modeling of Drug Toxicity 期刊论文
Methods in molecular biology (Clifton, N.J.), 2018, 卷号: 1754, 页码: 247-264
作者:  Lu, Jing;  Lu, Dong;  Fu, Zunyun;  Zheng, Mingyue;  Luo, Xiaomin
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532
作者:  Chen, Wen-hua;  Song, Shan-shan;  Qi, Ming-hui;  Huan, Xia-juan;  Wang, Ying-qing
收藏  |  浏览/下载:26/0  |  提交时间:2019/01/08


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