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上海药物研究所 [21]
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BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer
期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:
Lv, Yang
;
Lv, Xiaotong
;
Zhang, Jiahui
;
Cao, Guozhen
;
Xu, Changzhi
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/05/16
small cell lung cancer
BRD4
KEAP1
Nrf2
pentose phosphate pathway
Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 4, 页码: 22
作者:
Gao, Mengqing
;
Wang, Jin
;
Rousseaux, Sophie
;
Tan, Minjia
;
Pan, Lulu
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/11/04
Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum
期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 4
作者:
Yang, Fan
;
Hua, Qiang
;
Yao, Li-Gong
;
Liang, Lin-Fu
;
Lu, Yan-Hua
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/08/17
Soft coral
Litophyton nigrum
Nardosinane
Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer
期刊论文
NANO TODAY, 2021, 卷号: 36, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Xu, Zhiai
;
Li, Tianliang
;
Gao, Ang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/06/11
Tumor microenvironment
Prodrug nanovesicles
Cancer immunotherapy
Immunogenic cell death
Adaptive immune resistance
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer
期刊论文
ADVANCED SCIENCE, 2021, 页码: 12
作者:
Sun, Fang
;
Zhu, Qiurong
;
Li, Tianliang
;
Saeed, Madiha
;
Xu, Zhiai
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
glucose metabolism
immunogenic cell death
pancreatic cancer
photoimmunotherapy
prodrug nanoparticles
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction
期刊论文
INVESTIGATIONAL NEW DRUGS, 2020, 卷号: 38, 期号: 3, 页码: 700-713
作者:
Damaneh, Mohammadali Soleimani
;
Hu, Jian-Ping
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Tian, Chang-Qing
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  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
BET inhibitor
Cell proliferation
Apoptosis
Anti-cancer agent
BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis
期刊论文
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12
作者:
Li, Guang
;
Zheng, Yan-Hua
;
Xu, Li
;
Feng, Juan
;
Tang, Hai-Long
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/12/24
apoptosis
BRD4 inhibitor
G1 phase cell cycle checkpoint
multiple myeloma
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292
作者:
Zhang, Feng-cai
;
Sun, Zhong-ya
;
Liao, Li-ping
;
Zuo, Yu
;
Zhang, Dan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
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