Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum

doi:10.1016/j.fitote.2021.104906

	Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum
	Yang, Fan 1,2,3,4; Hua, Qiang 1,3; Yao, Li-Gong 2; Liang, Lin-Fu 5; Lu, Yan-Hua 1,3; An, Fa-Liang 1,3; Guo, Yue-Wei 2
刊名	FITOTERAPIA
	2021-06-01
卷号	151 页码:4
关键词	Soft coral Litophyton nigrum Nardosinane
ISSN号	0367-326X
DOI	10.1016/j.fitote.2021.104906
通讯作者	An, Fa-Liang(flan2016@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Further chemical investigation of the Xisha soft coral Litophyton nigrum has resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely linardosinenes D-G (1-4). The structures of new compounds were elucidated by extensive analyses of their spectroscopic data and by comparison with the reported data of known related ones. All compounds exhibited weak inhibitory effect against bromodomain-containing protein 4 (BRD4), a promising therapeutic target in various human diseases, at a concentration of 10 mu M.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[41876194]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000655328000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297032]
专题	中国科学院上海药物研究所
通讯作者	An, Fa-Liang; Guo, Yue-Wei
作者单位	1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China 3.Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Shanghai Normal Univ, Coll Life & Environm Sci, Dept Biol, 100 Guilin Rd, Shanghai 200234, Peoples R China 5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式 GB/T 7714	Yang, Fan,Hua, Qiang,Yao, Li-Gong,et al. Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum[J]. FITOTERAPIA,2021,151:4.
APA	Yang, Fan.,Hua, Qiang.,Yao, Li-Gong.,Liang, Lin-Fu.,Lu, Yan-Hua.,...&Guo, Yue-Wei.(2021).Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum.FITOTERAPIA,151,4.
MLA	Yang, Fan,et al."Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum".FITOTERAPIA 151(2021):4.