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上海药物研究所 [6]
厦门大学 [4]
清华大学 [2]
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期刊论文 [19]
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Structure-Based Survey of the Binding Modes of BACE1 Inhibitors
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889
作者:
Hu, Hangchen
;
Chen, Zhaoqiang
;
Xu, Xiang
;
Xuo, Yechun
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
BACE1
Alzheimer's disease
inhibitor
ligand binding mode
subsite
substructure
A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor
期刊论文
FEBS LETTERS, 2017, 卷号: 591, 期号: 21, 页码: 3615-3624
作者:
Zhang, Yang-xin
;
Wang, Shao-wei
;
Lu, Shuai
;
Zhang, Ling-xiao
;
Liu, Dong-qun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2017/12/20
Aggregation
Beta-amyloid Oligomer
Mimotope
Peptide
Vaccine
Differences in A beta brain networks in Alzheimer's disease and healthy controls
期刊论文
BRAIN RESEARCH, 2017, 卷号: 1655
作者:
Duan, Huoqiang
;
Jiang, Jiehui
;
Xu, Jun
;
Zhou, Hucheng
;
Huang, Zhemin
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Alzheimer's disease
beta-amyloid (A beta)-cascade
11C-PiB PET
Brain networks
Graph theoretical
Differences in A beta brain networks in Alzheimer's disease and healthy controls
期刊论文
BRAIN RESEARCH, 2017, 卷号: 1655, 页码: 77-89
作者:
Duan, Huoqiang[1]
;
Jiang, Jiehui[2]
;
Xu, Jun[3]
;
Zhou, Hucheng[4]
;
Huang, Zhemin[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/24
Alzheimer's disease
beta-amyloid (A beta)-cascade
11C-PiB PET
Brain networks
Graph theoretical
Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum
期刊论文
MOLECULAR NEUROBIOLOGY, 2016, 卷号: 53, 期号: 7, 页码: 4539-4547
作者:
Liu, Ying
;
Tan, Lan
;
Wang, Hui-Fu
;
Liu, Yong
;
Hao, Xiao-Ke
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2016/10/20
Alzheimer's Disease
Apoe
Amyloid Beta
Biomarker
Adni
Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease
期刊论文
Metallomics, 2016, 卷号: 8, 期号: 8, 页码: 782-789
作者:
Zhang, Zhong-Hao
;
Chen, Chen
;
Wu, Qiu-Yan
;
Zheng, Rui
;
Liu, Qiong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/05/09
Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 15, 页码: 3765-3769
作者:
Chen, Jing
;
Tao, Ling-Xue
;
Xiao, Wei
;
Ji, Sha-Sha
;
Wang, Jian-Rong
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Oxazino-indoles
Oxa-Pictet-Spengler reaction
Neuroprotective agent
Alzheimer's disease
SAR
Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 9, 页码: 2175-2186
作者:
Ning, Ruonan
;
Lei, Yun
;
Liu, Shuangzhu
;
Wang, Huan
;
Zhang, Rujun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Nicotine exerts neuroprotective effects against beta-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway
期刊论文
http://dx.doi.org/10.3892/ijmm.2014.1632, 2014
Xue, Mao Qiang
;
Liu, Xiao Xing
;
Zhang, Yan Ling
;
Gao, Feng Guang
;
薛茂强
;
高丰光
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
ACETYLCHOLINE-RECEPTORS
ALZHEIMERS-DISEASE
KINASE CASCADE
INDUCED APOPTOSIS
DENDRITIC CELLS
LUNG-CANCER
IN-VIVO
KAPPA-B
EXPRESSION
MITOCHONDRIA
Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 68, 页码: 270-283
作者:
Zou, Yiquan
;
Xu, Lei
;
Chen, Wuyan
;
Zhu, Yiping
;
Chen, Tiantian
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Alzheimer's disease
BACE1
C-terminus
Click chemistry
In situ screening assay
Pyrazole
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